| S4701 |
2-DG (2-Deoxy-D-glucose)
|
2-DG (2-Deoxy-D-glucose), an analog of glucose, is a glycolytic inhibitor with antiviral activity. 2-Deoxy-D-glucose induces apoptosis and inhibits Herpes Simplex Virus type-1 (HSV-1) receptor expression.
|
-
Signal Transduct Target Ther, 2025, 10(1):341
-
Nat Commun, 2025, 16(1):212
-
Cancer Commun (Lond), 2025, 10.1002/cac2.70036
|
|
| S2610 |
Lonidamine
|
Lonidamine is an orally administered small molecule hexokinase inactivator.
|
-
Signal Transduct Target Ther, 2025, 10(1):341
-
Cancer Lett, 2024, 589:216824
-
iScience, 2024, 27(10):110862
|
|
| S2155 |
LY2608204
|
LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.
|
-
Sci Rep, 2017, 7:44681
-
Nat Commun, 2016, 7:11463
|
|
| S3839 |
1-Deoxynojirimycin
|
1-Deoxynojirimycin (duvoglustat, moranolin) is a potent α-glucosidase inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.
|
-
J Biol Chem, 2022, 298(12):102643
|
|
| S3278 |
Kaempferol-3-O-neohesperidoside
|
Kaempferol 3-neohesperidoside (Kaempferol-3-O-neohesperidoside), a flavonoid isolated from the leaf extract of Primula latifolia Lapeyr. and Primula vulgaris Hudson, stimulates glycogen synthesis in rat soleus muscle via PI3K - GSK-3 pathway and MAPK - PP1 pathway.
|
|
|
| S2035 |
Epalrestat
|
Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM.
|
-
Cell Rep Med, 2023, 4(6):101056
-
Free Radic Biol Med, 2021, 163:220-233
-
J Agric Food Chem, 2020, 68(42):11747-11757
|
|