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Carbohydrate Metabolism Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S5426 Bromopyruvic acid (3-BP) Bromopyruvic acid (3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is an inhibitor of tumour cell energy Metabolism and a chemopotentiator of platinum drugs.
Signal Transduct Target Ther, 2025, 10(1):341
Alzheimers Res Ther, 2025, 17(1):72
iScience, 2024, 27(3):109246
S3918 4',7-Dimethoxy-5-Hydroxyflavone 4',7-Dimethoxy-5-Hydroxyflavone (4',7-dimethylapigenin, apigenin dimethylether, apigenin 7,4'-dimethyl ether) inhibits α-glucosidase and α-amylase enzymes and enhances 2-NBDG uptake in L6 cells.
Nat Cell Biol, 2022, 24(3):364-372
S4101 Voglibose Voglibose (AO 128) is an N-substituted derivative of valiolamine, excellent inhibitory activity against als-glucosidases and its action against hyperglycemia and various disorders caused by hyperglycemia.
G3 (Bethesda), 2020, 4;10(5):1585-1597
E4744New BI-9787 BI-9787 is a potent zwitterion inhibitor of ketohexokinase(KHK) with IC50 values of 12 nM and 12.8 nM for hKHK-A and hKHK-C. It exhibits good metabolic stability in rat hepatocytes and serves as a potent tool compound for in vitro and in vivo studies in rodents.
E8270New Eleutherol Eleutherol (Allium A) is a naphthalene extracted from the bulb of E. americana and a potent inhibitor of α-glucosidase with an IC50 of >1.00 μM. It also exhibits significant antifungal activity with MIC values between 7.8 µg/mL and 250 µg/mL. It can be used in research on antimicrobial infections and diabetes treatment.
S3245 Nodakenetin Nodakenetin (NANI), a plant-derived coumarin isolated from Angelica decursiva, inhibits α-glucosidase, PTP1B, rat lens aldose reductase (RLAR), AChE, BChE, and β-site amyloid precursor protein cleaving enzyme 1 (BACE1). This compound alters the protein expression of Bax and Bcl-2, and prompts mitochondrial apoptosis. It exhibits anti-tumour activity.
S2589 Miglitol Miglitol is an oral anti-diabetic drug.
E0477 N-Caffeoyl O-methyltyramine N-Caffeoyl O-methyltyramine is a class of alkaloid isolated from Cuscuta reflexa with strong inhibitory activity against α-glucosidase with IC50 of 103.58 μM.
E2846 FBPase-1 inhibitor-1 FBPase-1 inhibitor-1, an allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1), exhibits similar potency (IC50 = 3.4 μM using MG; = 4.0 μM in the coupled format) in these two distinct assays of FBPase-1 activity.
S0553 Butyl isobutyl phthalate  Butyl isobutyl phthalate (BIP), isolated from the rhizoid of Laminaria japonica, is a non-competitive inhibitor of α-glucosidase with IC50 of 38 μM. Butyl isobutyl phthalate displays a significant hypoglycemic effect and has the potential for diabetes treatment.
E3107 Andrographis Herba Extract Andrographis Herba Extract is obtained from the aerial part of Andrographis paniculata (Burm. F.) Nees, has various activities including antimicrobial and Antioxidant, antimalarial, antiangiogenic, anti-inflammatory, anti-diabetic, and in vitro α-glucosidase and α-amylase enzyme inhibitory activities.
E3333 Viburnum Dilatatum Extract Viburnum Dilatatum Extract is extracted from Viburnum Dilatatum, which has alpha-glucosidase inhibitory activities and an antihyperglycaemic action.
S0808 Ketohexokinase inhibitor 1 Ketohexokinase inhibitor 1 (PF-06835919, MDK1846) is a potent inhibitor of ketohexokinase (KHK) with IC50 of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively.
S3796 Rebaudioside A Rebaudioside A (Stevia Extract, Reb A, Glycoside A3, Stevioside A3), a natural sweetening ingredient extracted from the stevia leaf, is used in powder or liquid form to heighten sweetening intensity and improve taste. This compound is a steviol glycoside, α-glucosidase inhibitor with IC50 of 35.01 μg/ml. It can inhibit ATP-sensitive K+-channels.
S2949 KPLH1130 KPLH1130 is a specific inhibitor of pyruvate dehydrogenase kinase (PDK) that blocks macrophage polarization and attenuates proinflammatory responses.
S4793 Cedryl acetate Cedryl Acetate (Cedrol acetate, Cedranyl acetate), an acetylated from cedarwood oil, has been applied to chemistry for its properties as a chiral and cell signaling reagent with antifungal and immunotoxicity functions. Cedryl acetate exhibits α-glucosidase inhibitory activity.
S3300 Desoxyrhaponticin Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. This compound is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. It has apoptotic effect on human cancer cells.
Nat Metab, 2021, 10.1038/s42255-021-00479-4
S9378 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
Medical University of Bialystok, 2022, Vol. 79 No. 6 pp. 835-840, 2022
E3072 Paniculata Extract Paniculata Extract is extracted from Microcos paniculata L., which shows various biological functions including antioxidant activity and α-glucosidase inhibitory effect.
S3243 Zeaxanthin Zeaxanthin, the carotenoid alcohol participates in the xanthophyll cycle, activates the extrinsic apoptosis pathway which induces apoptosis on uveal melanoma cells with IC50 value 40.8 µM.