Rho

Other Cell Cycle Inhibitors

• Featured Inhibitors
• Inhibitors (25)
• Activator (1)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S8031	NSC 23766 Trihydrochloride	NSC 23766 Trihydrochloride is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.	J Orthop Translat, 2025, 54:152-166 Microbiol Spectr, 2025, 13(2):e0222124 Nat Commun, 2024, 15(1):8159
S7319	EHop-016	EHop-016 is a specific Rac GTPase inhibitor with an IC50 of 1.1 μM for Rac1 in MDA-MB-435 and MDA-MB-231 cells, equally potent inhibition for Rac3.	Microbiol Spectr, 2025, 13(2):e0222124 Biochem Biophys Res Commun, 2025, 766:151846 bioRxiv, 2025, 2025.07.31.668026
S7719	CCG-1423	CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription.	FASEB J, 2025, 39(7):e70505 Cell Rep, 2024, 43(4):113989 Bioact Mater, 2023, 26:413-424
S7686	ML141 (CID-2950007)	ML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 also protects neuroblastoma cells from metformin-induced apoptosis.	Cell Rep, 2025, 44(8):116025 Cell Mol Life Sci, 2025, 82(1):127 EMBO Rep, 2025, 26(21):5239-5269
S7482	EHT 1864 2HCl	EHT 1864 2HCl is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.	Cell Mol Life Sci, 2025, 82(1):127 Cancer Metab, 2025, 13(1):39 Sci Adv, 2025, 11(31):eads2310
S7293	ZCL278	ZCL278 is a selective Cdc42 GTPase inhibitor with Kd of 11.4 μM.	Am J Physiol Cell Physiol, 2025, 10.1152/ajpcell.00987.2024 Cell Death Dis, 2024, 15(11):867 Cancer Commun (Lond), 2023, 43(8):909-937
S1721	Azathioprine	Azathioprine (BW 57-322) is an immunosuppressive drug, inhibiting purine synthesis and GTP-binding protein Rac1 activation, used in the treatment of organ transplantation and autoimmune diseases.	Cancer Cell, 2025, 43(4):776-796.e14 J Extracell Vesicles, 2024, 13(4):e12426 Cell Rep, 2024, 43(8):114528
S8749	MBQ-167	MBQ-167 is a potent and dual inhibitor of Rac and Cdc42 with IC50s of 103 nM and 78 nM respectively, in metastatic breast cancer cells.	iScience, 2024, 27(6):110139 Nat Genet, 2022, 10.1038/s41588-022-01191-z Osteoarthritis Cartilage, 2022, S1063-4584(22)00035-8
S8469	CCG-203971	CCG-203971 is a novel small-molecule inhibitor of the Rho/MRTF/SRF pathway with the IC50 value of 0.64 μM for SRE.L. It inhibits Rho-mediated gene transcription.	Biomedicines, 2023, 11(9)2351 J Cell Physiol, 2020, 235(5):4790-4803 Small GTPases, 2020, 10.1080/21541248
S6000	CID44216842	CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively.	J Extracell Vesicles, 2024, 13(4):e12426 bioRxiv, 2023, 2023.07.23.550205
1 2