DYRK

Other Cell Cycle Inhibitors

CDK ROCK Wee1 Aurora Kinase Chk PLK APC MPS1 Rho Myc

Cat.No.	Product Name	Information	Product Use Citations
S7338	AZ191	AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.	PLoS One, 2024, 19(10):e0311655 Nucleic Acids Res, 2021, gkaa1290 Cell Death Dis, 2021, 12(1):125
S7327	ID-8	ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. This compound maintains its efficacy throughout extended culture periods.	Cell Chem Biol, 2022, 29(9):1368-1380.e5
S8395	INDY	INDY, a benzothiazole derivative is a potent and ATP-competitive inhibitor of Dyrk1A and Dyrk1B with an IC50 value of 0.24 μM and Ki value of 0.18 μM, respectively. This compound diminishes the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells.	Chin Med, 2025, 20(1):161
E7732	GNF4877	GNF4877 is an aminopyrazine and a potent inhibitor of GSK3β and DYRK1A with an IC50 of 16 nM and 6 nM, respectively. It blocks nuclear factor of activated T-cells (NFATc) nuclear export, promotes β-cell proliferation, and is useful for research on diabetes drug development.
E2853	GSK626616	GSK-626616 is a dual-specificity tyrosine-regulated kinase (DYRK3) inhibitor with an IC50 of 0.7 nM which is a potential therapy for the treatment of anaemia.
S3817	Harmine hydrochloride	Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs). Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.	Cell Death Discov, 2025, 11(1):282 Cancers (Basel), 2022, 14(2)326
S3406	LDN-192960	LDN-192960 (Compd 1) is a potent inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50 of 10 nM and 48 nM, respectively.	Colloids Surf B Biointerfaces, 2022, 209(Pt 1):112182
E2668	Cirtuvivint	Cirtuvivint (SM08502) is a potent and orally active inhibitor of CDC-like kinase (CLK) and a DYRK (dual-specificity tyrosine kinase) that targets mRNA splicing and is optimised for Wnt pathway inhibition. This compound inhibits serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupts spliceosome activity. It can be used for solid tumour research.
E0779	Paprotrain	Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.