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Proton Pump inhibitors

A proton pump plays a key role in cell respiration as a specical membrane protein. A proton pump includes (H+/K+ ATPase) the gastric hydrogen potassium ATPase which is the proton pump of the stomach. The gastric H+,K+-ATPase, which is responsible for gastric acid secretion, is a P2-type ATPase located in the apical membrane of parietal cells. The enzyme is an α/β heterodimer. The α subunit, which has cation-binding and ATP-binding sites, plays a crucial role in catalytic activity. The β subunit is responsible for functional expression.

Other Transmembrane Transporters Inhibitors

CFTR CRM1 Calcium Channel P-gp Sodium Channel ATPase Potassium Channel CD markers GLUT Amino acid transporter
Cat.No. Product Name Information Product Use Citations Product Validations
S1413 Bafilomycin A1 (Baf-A1) Bafilomycin A1 (Baf-A1) is a vacuolar H+-ATPase inhibitor with IC50 of 0.44 nM, and it is found to inhibit autophagy while inducing apoptosis.
Nature, 2025, 10.1038/s41586-025-09745-x
Cell Res, 2025, 10.1038/s41422-025-01085-9
Signal Transduct Target Ther, 2025, 10(1):81
Verified customer review of Bafilomycin A1 (Baf-A1)
S1389 Omeprazole Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.
Drug Metab Dispos, 2025, 53(4):100049
J Extracell Vesicles, 2024, 13(4):e12426
Phytomedicine, 2024, 135:156251
S4845 Rabeprazole Rabeprazole (LY307640) is an oral inhibitor of Proton Pump and blocks the production of acid by the stomach.
J Extracell Vesicles, 2024, 13(4):e12426
Sci Rep, 2024, 14(1):28163
Med Oncol, 2024, 41(8):188
S2105 Pantoprazole Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
Med Oncol, 2024, 41(8):188
Int J Mol Sci, 2022, 23-158572
Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x
S1354 Lansoprazole Lansoprazole (A-65006, AG-1749) is a proton pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase. This compound prevents the stomach from producing gastric acid.
Front Cell Dev Biol, 2021, 9:655559
J Virol, 2021, JVI.00190-21
Front Microbiol, 2019, 10:2790
S4099 Dexlansoprazole Dexlansoprazole (T 168390, TAK 390, (R)-Lansoprazole), the dextrorotatory enantiomer of lansoprazole, is a Proton Pump Inhibitor (PPI) formulated to have dual delayed-release properties. This compound selectively suppresses gastric acid secretion by direct inhibition of the H(+),K(+)-ATPase Proton Pump in the gastric parietal cell.
Food Chem Toxicol, 2025, 197:115262
J Immunother Cancer, 2024, 12(11)e009805
J Virol, 2021, JVI.00190-21
S5658 Omeprazole Sodium Omeprazole Sodium is the sodium salt form of omeprazole, which is a Proton Pump inhibitor and suppresses gastric acid secretion. This compound is a metabolism-dependent inhibitor (MDI) of CYP2C19.
Theranostics, 2021, 11(5):2364-2380
J Virol, 2021, JVI.00190-21
Biosci Rep, 2021, BSR20200842
S4075 Zinc Pyrithione Zinc Pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the Proton pump.
Cell Chem Biol, 2021, S2451-9456(21)00213-0
Biol Reprod, 2019, 100(2):468-478
Cell Syst, 2017, 4(6-:600-610
S3666 Ilaprazole Ilaprazole (IY-81149) is a new Proton Pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. It inhibits H+/K+-ATPase with an IC50 of 6.0 μM.
bioRxiv, 2025, 2025.05.19.654850
Med Oncol, 2024, 41(8):188
J Virol, 2021, JVI.00190-21
S4212 Tenatoprazole Tenatoprazole (TU-199,STU-Na) is a prodrug of the Proton Pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. This compound labels only the gastric H(+),K(+)-ATPase alpha-subunit, approximately 2.6 nM/mg of this chemical is bound to the H(+),K(+)-ATPase.
Viruses, 2024, 16(10)1566
J Virol, 2021, JVI.00190-21