CRM1 inhibitors
Other Transmembrane Transporters Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S7252 | Selinexor (KPT-330) | Selinexor (KPT-330, ATG-010) is an orally bioavailable selective CRM1 inhibitor. This compound is in Phase 2. |
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| S7580 | Leptomycin B (LMB) | Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM–10 nM. |
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| S8397 | Eltanexor (KPT-8602) | Eltanexor (KPT-8602, ONO-7706, ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20–211 nM in 10 AML lines after 3 days exposure. |
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| S7125 | KPT-185 | KPT-185 is a selective CRM1 inhibitor that induces growth inhibition and apoptosis in a panel of NHL cell lines with a median IC50 ~25 nM. |
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| S7707 | Verdinexor (KPT-335) | Verdinexor (KPT-335, ATG-527) is an orally bioavailable, selective XPO1/CRM1 inhibitor. |
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| S7251 | KPT-276 | KPT-276 is an orally bioavailable selective CRM1 inhibitor. |
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| S7551 | Piperlongumine | Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1; also an inhibitor of PI3K/Akt/mTOR in human breast cancer cells. |
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