Calcium Channel inhibitors/antagonists

Other Transmembrane Transporters Inhibitors

• Featured Inhibitors
• Inhibitors (74)
• Modulators (8)
• Chemicals (8)
• Agonists (5)
• Activators (2)
• Agonists (13)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7924	Bay K 8644	Bay K 8644 is a racemate. Bay K 8644 is a potent, selective activator of L-type Ca2+ channel with an IC50 of 17.3 nM.	J Neurotrauma, 2025, 10.1177/08977151251374286 EMBO Rep, 2024, 25(11):4777-4802 ACS Nano, 2021, 10.1021/acsnano.1c03517
S7914	ISX-9 (Isoxazole 9)	ISX-9 (Isoxazole 9) is a synthetic promoter of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). ISX-9 (Isoxazole 9) activates multiple pathways including TGF-β induced epithelial–mesenchymal transition (EMT) signalling, canonical and non-canonical Wnt signalling at different stages of cardiac differentiation.	iScience, 2025, 28(3):112015 Front Cell Dev Biol, 2025, 13:1513163 Cell Regen, 2025, 14(1):18
S4202	Verapamil HCl	Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmia agent. Verapamil inhibits both permeability-glycoprotein (P-gp) and CYP3A4.	Cancer Cell, 2025, 43(4):776-796.e14 Nat Commun, 2025, 16(1):7115 Blood Sci, 2025, 7(2):e00236
S2403	Tetrandrine	Tetrandrine, a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a Calcium Channel blocker.	PLoS Pathog, 2025, 21(8):e1013342 Pharmacol Res, 2024, 207:107314 mBio, 2024, e0228723.
S1808	Nifedipine	Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.	Dis Model Mech, 2025, 18(6)dmm052220 J Immunother Cancer, 2024, 12(11)e009805 Laryngoscope Investig Otolaryngol, 2023, 8(5):1390-1400
S2721	Nilvadipine	Nilvadipine (ARC029, FR34235, FK235) is a potent Calcium Channel blocker with an IC50 of 0.03 nM.	Cell Death Differ, 2024, 10.1038/s41418-024-01418-y J Immunother Cancer, 2024, 12(11)e009805 Nat Commun, 2022, 13-1:6117
S1905	Amlodipine	Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.	J Immunother Cancer, 2024, 12(11)e009805 Cancer Med, 2024, 13(11):e7291 Acta Pharm Sin B, 2023, 13(10):4217-4233
S2030	Flunarizine 2HCl	Flunarizine 2HCl (KW-3149, R14950) is a dihydrochloride salt form which is a Calcium Channel blocker with a Ki of 68 nM.	Sci Adv, 2023, 9(15):eadf2695 J Pers Med, 2022, 12(2)258 Hum Cell, 2022, 10.1007/s13577-022-00671-y
S1293	Cilnidipine	Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.	J Immunother Cancer, 2024, 12(11)e009805 Nat Commun, 2021, 12(1):3907 Cell Discov, 2020, 6(1):96
S1748	Nisoldipine	Nisoldipine (Sular, BAY K 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.	J Immunother Cancer, 2024, 12(11)e009805 Biomed Pharmacother, 2022, 145:112432 iScience, 2022, 25(10):105068
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