Home GPCR & G Protein Prostaglandin Receptor

Prostaglandin Receptor Agonists

Cat.No. Product Name Information Product Use Citations Product Validations
S3726 Selexipag Selexipag (NS-304, ACT-293987) is an orally active, first-in-class, selective prostacyclin IP receptor agonist with Ki value of 260 nM for human IP, whereas Ki values > 10,000 nM are measured at the other human G-protein-coupled prostanoid receptors (EP1-4, DP, FP and TP).
J Immunother Cancer, 2024, 12(11)e009805
Biol Pharm Bull, 2022, 10.1248/bpb.b21-01057
Front Med (Lausanne), 2021, 8:742436
S1407 Bimatoprost Bimatoprost (AGN 192024) is a prostaglandin analogue used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
PLoS Pathog, 2020, 16;16(3):e1008341
Invest Ophthalmol Vis Sci, 2018, 59(15):5912-5923
S0325 Treprostinil sodium Treprostinil sodium is a potent agonist of DP1, EP2 and IP receptors with Ki 4.4 nM, 3.6 nM and 32 nM, respectively.
Eur J Pharm Sci, 2025, 214:107287
S4851 Tafluprost Tafluprost (AFP-168,MK2452) is a novel prostaglandin analog with a high affinity for the fluoroprostaglandin (FP) receptor PGF2α. A prostanoid selective FP receptor agonist.
S9327 Carboprost Carboprost is a synthetic prostaglandin analogue of PGF2α with oxytocic properties.
E4846 Treprostinil Treprostinil is a potent agonist of DP1 and EP2 with EC50 of 0.6 nM and 6.2 nM for DP1 and EP2 receptors, respectively. It is a vasodilator used to treat pulmonary arterial hypertension and improves mitochondrial impairment in vitro.
S0111 Taprenepag Taprenepag (CP-544326) is a potent and selective prostaglandin EP2 agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively.
E0053 Evatanepag Evatanepag (CP-533536 free acid) is a potent and selective EP2 receptor agonist with an IC50 of 50 nM for rEP2.
S5819 MRE-269 (ACT-333679) MRE-269 (ACT-333679) is a prostaglandin I2 (IP) receptor agonist with a binding affinity for the human IP receptor that is 130-fold greater than that for other human prostanoid receptor.
S3738 Travoprost Travoprost (Travoprostum) is a PGF2a analog that was launched as an ophthalmic solution administered topically for the treatment of elevated intraocular hypertension as a result of open-angle glaucoma, a common optic neuropathy, and a leading cause of blindness. It can act as an agonist of prostaglandin F receptor.
S5056 Dinoprost tromethamine Dinoprost Tromethamine (Dinolytic, PGF2-alpha tham, Zinoprost, Prostin F2 alpha, Dinoprost Trometamol) is a synthetic analogue of the naturally occurring prostaglandin F2 alpha, which stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum.
E2146 Iloprost Iloprost (Ciloprost, ZK 36374, Ventavis) is a prostacyclin (PGI2) analogue and is a potent agonist of the prostacyclin IP receptor and the prostaglandin E2 (PGE2) receptor subtype EP1. It exhibits high binding affinity for EP1 and IP receptors with Ki values of 1.1 nM and 3.9 nM, respectively.
S4415 Misoprostol Misoprostol (SC29333) is a synthetic Prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labour, and to induce abortion. This compound can be used to induce animal models of Spontaneous Abortion.
S3003 Prostaglandin E2 (PGE2) Prostaglandin E2 (PGE2, Dinoprostone) plays important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. It is easy to discolour when stored in liquid environment for a long time. It is recommended to store it in powder form and try to use it as soon as possible!
Transl Neurodegener, 2025, 14(1):43
J Exp Clin Cancer Res, 2025, 44(1):198
JCI Insight, 2025, e177545