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Pantoprazole sodium Proton Pump inhibitor

Name: Pantoprazole sodium
Brand: Selleck Chemicals
SKU: S4538
Rating: 5 (2 reviews)

Cat.No.S4538

Pantoprazole (SKF96022, BY-1023) is a Proton Pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.

Chemical Structure

Molecular Weight: 405.35

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Quality Control

Batch: Purity: 99.85%

99.85

Related Targets	CFTR CRM1 CD markers AChR Calcium Channel Sodium Channel Potassium Channel GABA Receptor TRP Channel ATPase
Other Proton Pump Inhibitors	Bafilomycin A1 (Baf-A1) Ilaprazole Tenatoprazole Revaprazan Hydrochloride Ilaprazole sodium PF-3716556 Ufiprazole

Chemical Information, Storage & Stability

Molecular Weight	405.35	Formula	C₁₆H₁₄F₂N₃NaO₄S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	138786-67-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	SKF96022 sodium, BY-1023 sodium			Smiles	COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]

Solubility

In vitro
Batch:

DMSO : 81 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 81 mg/mL

Ethanol : 81 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	Proton pump HIF-1α (H+/K+)-ATPase
In vitro	pantoprazole (PPZ) inhibits tumour cell proliferation, induces apoptosis and decreases the expression of HIF-1α protein. Pantoprazole affects the intracellular distribution of HIF-1α in SGC-7901 cells, which might be one of the mechanisms of its chemosensitising effect on cancer cells.
In vivo	After PPZ treatment, apoptotic cell death is seen selectively in cancer cells and is accompanied with extracellular signal-regulated kinase deactivation. By contrast, normal gastric mucosal cells show resistance to PPZ-induced apoptosis through the overexpression of antiapoptotic regulators including HSP70 and HSP27. In a xenograft model of nude mice, administration of PPZ significantly inhibits tumourigenesis and induces large-scale apoptosis of tumour cells.
References	[1] https://pubmed.ncbi.nlm.nih.gov/26870273/ [2] https://pubmed.ncbi.nlm.nih.gov/22248271/ [3] https://www.researchgate.net/publication/288803659_Effect_of_pantoprazole_on_hypoxia-inducible_factor-1a_expression_in_human_gastric_adenocarcinoma_cell_line_SGC-7901 [4] https://pubmed.ncbi.nlm.nih.gov/15623654/

Tech Support

Handling Instructions

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