HMG-CoA Reductase inhibitors
Other Metabolism Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S1792 | Simvastatin (MK-733) | Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. |
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| S1759 | Pitavastatin (NK-104) Calcium | Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis. |
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| S3036 | Pravastatin (CS-514) Sodium | Pravastatin sodium (CS-514) is an HMG-CoA Reductase inhibitor against sterol synthesis with IC50 of 5.6 μM. |
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| S2061 | Lovastatin (Mevinolin, MK-803) | Lovastatin is an inhibitor of HMG-CoA reductase with IC50 of 3.4 nM in a cell-free assay, used for lowering cholesterol (hypolipidaemic agent). Lovastatin triggers autophagy. |
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| S5715 | Atorvastatin | Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Atorvastatin activates autophagy. |
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| S1909 | Fluvastatin Sodium | Fluvastatin Sodium inhibits HMG-CoA reductase activity with IC50 of 8 nM in a cell-free assay. |
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| S2169 | Rosuvastatin calcium | Rosuvastatin calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay. |
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| S2077 | Atorvastatin Calcium (CI-981) | Atorvastatin Calcium is an inhibitor of HMG-CoA reductase used as a cholesterol-lowering medication that blocks the production of cholesterol. Atorvastatin Calcium induces apoptosis and autophagy. |
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| S4223 | Mevastatin | Mevastatin (ML-236B, Compactin) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. |
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| S5713 | Pravastatin | Pravastatin(CS-514) is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. |
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