Dehydrogenase inhibitors
Other Metabolism Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S8611 | Vorasidenib (AG-881) | Vorasidenib (AG-881) is an orally available inhibitor of mutated forms of both isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2). |
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| S6675 | (R)-GNE-140 | (R)-GNE-140 is an inhibitory agent for LDHA, LDHB, and LDHC, with IC50 values of 3 nM and 5 nM for LDHA and LDHB, respectively. (R)-GNE-140 is 18 times more potent than its S isomer. |
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| S2776 | CPI-613 (Devimistat) | Devimistat (CPI-613), a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in NCI-H460 cell line, disrupts tumor cell mitochondrial metabolism. CPI-613 induces apoptosis in pancreatic cancer cells. Phase 2. |
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| S1680 | Tetraethylthiuram disulfide (Disulfiram) | Disulfiram is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD). |
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| S8205 | AG-221 (Enasidenib) | Enasidenib (AG-221) is a first-in-class, oral, potent, reversible, selective inhibitor of the IDH2 mutant enzyme. |
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| S5097 | Methotrexate disodium | Methotrexate sodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis. |
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| S2302 | Glycyrrhizin (Glycyrrhizic Acid, NSC 167409) | Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1 (high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO). |
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| S8615 | Sodium Dichloroacetate (DCA) | DCA (Sodium Dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium Dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumour growth. |
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| S4169 | Teriflunomide | Teriflunomide (A77 1726, HMR-1726) is the active metabolite of leflunomide, inhibiting pyrimidine de novo synthesis by blocking the enzyme dihydroorotate Dehydrogenase, used as an immunomodulatory agent. |
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| S1247 | Leflunomide | Leflunomide is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of this compound is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). This chemical is also an agonist of the AhR. |
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