Home Metabolism Carbonic Anhydrase

Carbonic Anhydrase

Other Metabolism Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S2866 U-104 (SLC-0111) U-104 (MST-104, NSC 213841, SLC-0111, WBI-5111) is a potent Carbonic Anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, with very low inhibition for CA I and CA II.
Eur Thyroid J, 2025, 14(3)e250022
Nat Immunol, 2023, 24(11):1867-1878
Front Oncol, 2023, 13:1118268
Verified customer review of U-104 (SLC-0111)
S4506 Acetazolamide Acetazolamide (Diamox), a potent Carbonic Anhydrase (CA) inhibitor, is commonly used in clinical practice as an immediate and readily available option for acute reduction of intraocular pressure (IOP).
Commun Biol, 2025, 8(1):28
Eur Thyroid J, 2025, 14(3)e250022
Cell Commun Signal, 2024, 22(1):383
S1438 Topiramate Topiramate (MCN 4853, RWJ 17021) is a multi-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and Carbonic Anhydrase, used to treat epilepsy.
J Headache Pain, 2025, 26(1):182
Commun Biol, 2025, 8(1):28
Cell Rep, 2022, 40(5):111153
S3178 Brinzolamide Brinzolamide (AL-4862) is a potent carbonic anhydrase II inhibitor with IC50 of 3.19 nM.
Cell Rep, 2025, 44(4):115450
Commun Biol, 2025, 8(1):28
bioRxiv, 2024, 2024.03.13.584872
S9742 Indisulam (E7070) Indisulam (E7070), a sulfonamide anticancer agent, is a potent Carbonic Anhydrase (CA) inhibitor that inhibits cytosolic isozymes I and II, and transmembrane, tumour-associated isozyme IX. Indisulam suppresses the expression of cyclin E and phosphorylation of CDK2, both of which are essential for the G1 to S transition.
Nat Commun, 2025, 16(1):9754
Oncogenesis, 2024, 13(1):25
Cancer Cell, 2022, S1535-6108(22)00312-9
S1375 Dorzolamide HCl Dorzolamide (MK-507, L-671152) HCl is a water-soluble, potent inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM, respectively, used as anti-glaucoma agent.
Neuro Oncol, 2021, noab156
ETD, 2020, N/A
S1736 Methocarbamol Methocarbamol (AHR 85) is a carbonic anhydrase inhibitor, used as a central muscle relaxant to treat skeletal muscle spasms.
Cancer Res Commun, 2025, 10.1158/2767-9764.CRC-24-0433
S3697 Mafenide hydrochloride Mafenide is a sulfonamide that inhibits the enzyme Carbonic Anhydrase and is used as topical anti-infective, especially in burn therapy.
ETD, 2020, N/A
S4725 Benzenesulfonamide Benzenesulfonamide (Benzenesulphonamide, Benzosulfonamide, Phenyl sulfonamide, Benzene sulfonamide) is an inhibitor of carbonic anhydrases.
Br J Pharmacol, 2016, 173(6):1018-32
S2603 Tioxolone Tioxolone (Thioxolone) is a metalloenzyme Carbonic Anhydrase I inhibitor with a Ki of 91 nM.