Home Metabolism HMG-CoA Reductase

HMG-CoA Reductase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
E6038 Pitavastatin Pitavastatin (NK-104) is a highly potent inhibitor of HMG-CoA Reductase with an IC50 of 6.8 nmol/L, which significantly enhances LDL receptor activity and lowers LDL cholesterol (LDL-C) levels. It also inhibits cholesterol synthesis in vitro and has the potential to manage hypercholesterolemia and reducing cardiovascular risk.
Nat Commun, 2025, 16(1):5360
Biochem Biophys Res Commun, 2025, 742:151094
JCI Insight, 2024, 9(24)e178535
S8302 SR-12813 SR-12813 is a pregnane X receptor (PXR) agonist and HMG-CoA reductase inhibitor with an IC50 of 850 nM.
Front Pharmacol, 2024, 15:1488367
Evid Based Complement Alternat Med, 2021, 2021:4358163
Cell Death Dis, 2019, 10(10):777
S2664 Clinofibrate Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) with IC50 of 0.47 mM, is a lipid-lowering agent used for controlling high cholesterol and triacylglyceride levels in the blood.
Carcinogenesis, 2020, 7;bgaa036
E4981 Fluvastatin Fluvastatin is a competitive inhibitor of HMG-CoA reductase with an IC50 value of 40 and 100 nM in human liver microsomes. This compound also exerts cytoprotective effects against oxidative stress through the Nrf2-dependent antioxidant pathway.
JCI Insight, 2024, 9(24)e178535
E4821 Simvastatin acid (ammonium) Simvastatin acid (Tenivastatin) ammonium is a potent inhibitor of HMG-CoA reductase (HMGCR). This compound also decreases Indoxyl sulfate-induced reactive oxygen species (ROS) production in human cardiomyocytes and regulates the expression of OATP3A1 in these cells.
E1341 Cerivastatin sodium Cerivastatin sodium, a sodium salt of cerivastatin, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with Ki of 1.3 nM. It is also a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microgram doses.
E4792 Atorvastatin calcium hydrate Atorvastatin calcium hydrate (Totalip) is a potent inhibitor of the HMG-CoA Reductase. It is used as a potent hypolipidemic agent to reduce the elevated total-cholesterol, low-density lipoprotein (LDL), apolipoprotein B (apo B), and triglyceride (TG) levels, and to increase the high-density lipoprotein cholesterol (HDL-C) level in patients with primary hypercholesterolemia and mixed dyslipidemia.
E2286 Dihydrolanosterol Dihydrolanosterol (24,25-Dihydrolanosterol; Dihydrolanosterin; Lanostenol) inhibits cholesterol biosynthesis by promoting ubiquitination and degradation of HMG-CoA Reductase.
E2741 7-ketocholesterol 7-Ketocholesterol (7-Oxocholesterol), is a bioactive sterol and prominent cholesterol oxidation product, is a strong inhibitor of HMG-CoA Reductase and cytochrome P450 7A1. It enhances oxidative stress, endoplasmic reticulum stress, and apoptosis in macrophages.