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Perillyl alcohol Ras chemical

Cat.No.S3853

Perillyl alcohol (Perilla alcohol, Isocarveol) is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants.
Perillyl alcohol Ras chemical Chemical Structure

Chemical Structure

Molecular Weight: 152.23

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Quality Control

Batch: S385301 Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 152.23 Formula

C10H16O

 Storage (From the date of receipt) 2 years  -20°C  liquid
CAS No. 536-59-4 Download SDF Storage of Stock Solutions

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In vitro
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

In vitro
In vitro, Perillyl alcohol induces cell cycle arrest and apoptosis, inhibits the isoprenylation of small G proteins (21–26 kDa) involved in signal transduction and affects differential gene regulation. Perillyl alcohol (POH) inhibits cell proliferation in a dose-dependent manner in all cell lines tested (KPL-1, MCF-7, MKL-F and MDA-MB-231). POH at a dose of 500μM has a cytostatic effect, in which growth inhibition is due to accumulation of cells in G1-phase. Cell cycle progression is preceded by a decrease in G1 cyclins (cyclin D1 and E), followed by an increase in p21Cip1/Waf1 and a decrease in proliferating cell nuclear antigen level.
In vivo
Perillyl alcohol (POH) at a dose of 75mg/kg administered intraperitoneally three times a week throughout the entire 6-week experimental period suppresses orthotopically transplanted KPL-1 tumour cell growth and regional lymph node metastasis in a nude mouse system. POH inhibits both ER-positive and -negative human breast cancer cell growth in vitro, and suppressed growth and metastasis in vivo.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00608634 Completed
Precancerous Condition
University of Arizona|National Cancer Institute (NCI)|Arizona Disease Control Research Commission
 May 2004 Phase 2

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