Ferroptosis inhibitors/inducers
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S7699 | Liproxstatin-1 | Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM. |
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| S8155 | RSL3 | RSL3 ((1S,3R)-RSL3) is a ferroptosis activator in a VDAC-independent manner, exhibiting selectivity for tumour cells bearing oncogenic RAS. RSL3 binds, inactivates GPX4 and thus mediates GPX4-regulated ferroptosis. |
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| S7242 | Erastin | Erastin is a Ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumour cells bearing oncogenic RAS. Solutions are unstable and should be fresh-prepared. |
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| S7243 | Ferrostatin-1 (Fer-1) | Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with an EC50 of 60 nM. |
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| S8877 | Imidazole Ketone Erastin (IKE) | Imidazole Ketone Erastin (IKE) is a potent, selective, and metabolically stable system xc– inhibitor and inducer of Ferroptosis. |
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| S5742 | Deferoxamine mesylate | Deferoxamine mesylate is the mesylate salt of Deferoxamine, which forms iron complexes and is used as a chelating agent. Deferoxamine is a ferroptosis inhibitor that stabilises HIF-1α expression and improves HIF-1α transactivity in hypoxic and hyperglycaemic states in vitro. Deferoxamine decreases beta-amyloid (Aβ) deposition and induces autophagy.Please do not prepare stock solutions with normal saline or PBS, as precipitation may occur. |
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| S1166 | Cisplatin | Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumour cells. Cisplatin activates ferroptosis and induces autophagy.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. |
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| S7397 | Sorafenib (BAY 43-9006) | Sorafenib is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity. |
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| S1792 | Simvastatin (MK-733) | Simvastatin is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. |
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| S1077 | SB202190 | SB202190 is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. This compound inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. It significantly suppresses Erastin‐dependent ferroptosis. |
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