Potassium Channel Modulators

Featured Inhibitors
Inhibitors (53)
Modulators (3)
Chemical (1)
Agonist (1)
Activators (17)
Agonists (3)

Cat.No.	Product Name	Information	Product Use Citations
E4788	Nigericin	Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome.	Cell Mol Immunol, 2025, 22(11):1478-1490 Cell Death Dis, 2025, 16(1):465 Stem Cell Res Ther, 2025, 16(1):233
S0075	ICA-110381	ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 exhibits KCNQ2/Q3 agonist activity with EC50 of 0.38 μM and KCNQ1 antagonist activity with IC50 of 15 μM, respectively.
E0034	CyPPA	CyPPA is a subtype-selective positive modulator of SK channels with EC50s of 5.6 μM and 14 μM for hSK3 and hSK2, respectively. This compound is inactive on both hSK1 and hIK channels.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

E4788

Nigericin

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome.

Cell Mol Immunol, 2025, 22(11):1478-1490

Cell Death Dis, 2025, 16(1):465

Stem Cell Res Ther, 2025, 16(1):233

S0075

ICA-110381

ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 exhibits KCNQ2/Q3 agonist activity with EC50 of 0.38 μM and KCNQ1 antagonist activity with IC50 of 15 μM, respectively.

E0034

CyPPA

CyPPA is a subtype-selective positive modulator of SK channels with EC50s of 5.6 μM and 14 μM for hSK3 and hSK2, respectively. This compound is inactive on both hSK1 and hIK channels.