Potassium Channel Activators

Cat.No.	Product Name	Information	Product Use Citations
S1971	Nicorandil	Nicorandil (SG-75) is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP).	J Immunother Cancer, 2024, 12(11)e009805 J Cardiovasc Pharmacol Ther, 2022, 27:10742484221088655 BMC Cardiovasc Disord, 2021, 21(1):302
S4734	Retigabine 2HCl	Retigabine 2HCl (D-23129) is a novel anticonvulsant with activity in a broad range of seizure models. The mechanism of action involves opening of neuronal K(V)7.2-7.5 (formerly KCNQ2-5) voltage-activated K(+) channels.	J Biol Chem, 2021, S0021-9258(21)00985-6 Front Physiol, 2021, 12:790580 SSRN, 2021, 25 Pages
S2562	Hydralazine HCl	Hydralazine HCl is a hydrochloride salt of hydralazine, which is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles.	J Immunother Cancer, 2024, 12(11)e009805 Acta Pharm Sin B, 2023, 13(1):142-156 Biogerontology, 2016, 17(5-6):907-920
S1383	Minoxidil	Minoxidil (U-10858) is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. This compound is an ATP-sensitive Potassium Channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth.	Oncotarget, 2016, 7(43):69703-69717
S0462	NS-1619	NS-1619 is a selective activator of large conductance Ca2+-activated K+-channels.	Korean J Physiol Pharmacol, 2024, 28(5):469-478
S6978	VU0071063	VU0071063 activates heterologously expressed Kir6.2/SUR1 channels with an EC50 of 7 μM, dose dependently and reversibly hyperpolarises the β-cell membrane potential, which, in turn, inhibits glucose-stimulated Ca²⁺ entry and insulin secretion.
S0050	ML277	ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4.
S0311	SKA-31	SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively.
S6559	ML-297	ML-297 (VU 0456810, CID 56642816) is a potent and selective activator of Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) channel with EC50 of 0.16 μM and 1.8 μM for GIRK1/2 and GIRK1/4, respectively. This compound is potential for the treatment of epilepsy.
S6553	ML213	ML213 (CID-3111211) is a selective KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) Potassium Channel opener with EC50 of 230 nM and 510 nM, respectively.
E0325	NS3623	NS3623 is an activator of human ether-a-go-go-related gene hERG1/KV11.1 potassium channels. This compound activates the IKr and Ito currents and has antiarrhythmic effect. It has a dual mode of action, being an inhibitor of hERG1 channels.
S0144	ICA 069673	ICA 069673 (compound 51) is an orally active, potent and selective KCNQ2/Q3 potassium channel activator with EC50 of 0.69 μM and 14.3 μM for KCNQ2/Q3 and KCNQ3/Q5, respectively.
S6572	ML335	ML335 is a potent and selective TREK-1/2 activator. This compound is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively.
E0030	NS309	NS309 is a potent and selective activator of human Ca²⁺ -activated K⁺ channels of SK and IK types with an EC50 of 150 nM for hSK3 channel, and displays no activity at BK channels.
E5975^New	Ebio1	Ebio1 is a subtype-selective activator of the voltage-gated Potassium Channel KCNQ2 that enhances conductance through a unique twist-to-open mechanism. It induces conformational changes in the S6 helix, increasing channel activity at a saturating voltage (+50 mV).
S4630	Diazoxide	Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.	J Immunother Cancer, 2024, 12(11)e009805 Br J Pharmacol, 2022, 10.1111/bph.15896 Free Radic Biol Med, 2017, 112:616-630
S0467	Emodepside	Emodepside (QHT06, BAY 44-4400, PF 1022-221), a semisynthetic derivative of PF1022A, is a cyclooctadepsipeptide with broad-spectrum anthelmintic activity. This compound activates Ca-dependent SLO-1-like K channels.	Am J Vet Res, 2025, 1-6.