MMP Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S7157 | Ilomastat (GM6001) | Ilomastat (GM6001) is a broad spectrum matrix metalloprotease (MMP) inhibitor with Ki values of 0.4 nM, 0.5 nM, 27 nM, 3.7 nM, 0.1 nM, 0.2 nM, 3.6 nM, 13.4 nM, and 0.36 nM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-14, and MMP-26, respectively. |
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| S7155 | Batimastat (BB-94) | Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. It also inhibits the activity of other metalloproteases, such as ADAM17. |
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| S7430 | SB-3CT | SB-3CT is an effective and selective gelatinase inhibitor with Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively. |
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| S8966 | T-5224 | T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects. T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription. |
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| S7156 | Marimastat (BB-2516) | Marimastat (BB-2516, TA2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 values of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7, respectively. This compound has reached Phase 3. |
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| S2333 | Nobiletin | Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. |
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| S0769 | MMP-9-IN-1 | MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). This compound selectively targets the hemopexin (PEX) domain of MMP-9 with Kd of 2.1 μM. |
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| S8072 | NSC 405020 | NSC 405020 is a noncatalytic inhibitor of MT1-MMP, directly interacts with PEX domain of MT1-MMP, affects PEX homodimerization but not catalytic activity of MT1-MMP. |
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| S5696 | JNJ0966 | JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen. |
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| S5543 | 1, 10-Phenanthroline monohydrate | 1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases. |
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| S3610 | Cordycepin | Cordycepin (3'-Deoxyadenosine) is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly. It has very potent anti-cancer, anti-oxidant and anti-inflammatory activities. |
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| S9052 | Auraptene | Auraptene (7-geranyloxycoumarin) is a natural coumarin derived from citrus plants and possesses valuable pharmacological properties, including anticarcinogenic, anti-inflammatory, antihelicobacter, antigenotoxic, and neuroprotective effects. This compound inhibits matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8 and chemokine (C-C motif) ligand-5(CCL5). |
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| S5465 | Morroniside | Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. This compound has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression. |
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| S6830 | o-Phenanthroline | o-Phenanthroline (1,10-Phenanthroline, phen), a hypoxia-mimicking agent, is a non-specific matrix metalloproteinase (MMP) inhibitor with IC50 of 110.5μM for Collagenase. This compound reduces the expression of MMP3 and MMP13 mRNA levels during chondrogenic differentiation of human chondrocytes (hChs), as well as after TNFα/IL-1β exposure in an explant model. It is also a metal chelator which prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+ that absorbs maximally at 510 nm. |
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| S5752 | Abametapir | Abametapir (HA-44, BRN 0123183), the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development. |
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| S4964 | Lactobionic acid | Lactobionic acid (Galactosylgluconic acid), an α-hydroxyacid (AHA) with antioxidation activity, is used in the development of cosmeceuticals for skin. This compound inhibits matrix-metalloproteinase (MMP) activity. |
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| S0341 | T-26c | T-26c is a highly potent and selective inhibitor of matrix metalloproteinase-13 (MMP-13) with IC50 of 6.9 pM, more than 2600-fold selectivity over other related metalloenzymes. |
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| E0073 | CL-82198 | CL-82198 is a selective, orally bioavailable MMP-13 inhibitor with an IC50 of 3.2 μM. |
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| S4005 | Doxycycline HCl | Doxycycline HCl is a tetracycline antibiotic that commonly used to treat a variety of infections, and also a MMP inhibitor. | ||
| S0923 | Isoliquiritin apioside | Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. This compound possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity. | ||
| S3590 | Triolein | Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes. | ||
| S4884 | Trans-Zeatin | Trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. This compound inhibits UVB-induced MMP-1 expression, c-Jun activation and phosphorylation of ERK, JNK and p38 MAP kinases (MAPKs) dose-dependently. | ||
| S3309 | Solasodine | Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. This compound reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). It downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. This chemical also reduces PI3K/Akt signalling pathways and downregulates expression of miR-21. | ||
| S9386 | Polygalacic acid | Polygalacic acid is the triterpenoid tetrahydroxyacid isolated from Polygala paenea L.. This compound (0-100 μM; 24 hours) significantly decreases the mRNA expressions of MMP-3, MMP-9, MMP-13 and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. | ||
| S9909 | ARP 100 | ARP 100 (MMP-2 Inhibitor III, Compound 10a) is a potent and selective inhibitor of MMP-2 with an IC50 of 12 nM and displays less inhibitory activity at MMP-9, MMP-3, MMP-1 and MMP-7 with IC50s of 200 nM, 4500 nM, >50,000 nM and >50,000 nM respectively. | ||
| S5159 | Doxycycline | Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor. |
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| S4163 | Doxycycline Hyclate | Doxycycline Hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is also an inhibitor of matrix metallo-proteinases (MMP). |
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| S7434 | TAPI-1 | (S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP). |
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| S8660 | GI254023X (GI4023) | GI254023X (GI 4023, SRI028594) is a selective inhibitor of ADAM10 with 100-fold selectivity for ADAM10 over ADAM17. The IC50 values for recombinant ADAM10 and ADAM17 are 5.3 nM and 541 nM, respectively. GI254023X can inhibit MMP9. |
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| S0752 | AUDA | AUDA (compound 43) is a potent inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 18 nM and 69 nM for the mouse sEH and human sEH, respectively. This compound has anti-inflammatory activity that reduces the protein expression of MMP-9, IL-1β, TNF-α and TGF-β. It downregulates Smad3 and p38 signalling pathways. | ||
| E3640 | Dendrobii caulis Extract | Dendrobii Caulis Extract is extracted from Dendrobii Caulis, which can protect fibroblasts against UVA-induced photoaging via JNK/c-Jun/MMPs pathway. | ||
| E0783 | SM-7368 | SM-7368 is a potent NF-κB inhibitor that targets downstream of MAPK p38 activation, also inhibits TNF-α-induced MMP-9 upregulation. |
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