Endogenous Metabolite inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S5259 β-nicotinamide mononucleotide (NMN) Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction, is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.
Nat Commun, 2025, 16(1):212
MedComm (2020), 2025, 6(3):e70075
PLoS Pathog, 2025, 21(5):e1013163
S9793 4-HNE (4-Hydroxynonenal) 4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.
Nat Commun, 2022, 13(1):5545
S5992 Heparan Sulfate Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.
Mol Ther Methods Clin Dev, 2025, 33(1):101426
iScience, 2024, 27(6):110120
bioRxiv, 2024, 2024.05.23.595417
S2935 Nicotinamide Riboside Chloride (NR-Cl) Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside (NR). NR is a new form of pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide (NAD) or NAD+. Nicotinamide Riboside Chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide Riboside Chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide Riboside Chloride is used in dietary supplements.
bioRxiv, 2025, 2025.07.10.663928
bioRxiv, 2025, 2025.01.06.631511
Front Physiol, 2023, 14:1164287
S5109 Ademetionine (S-Adenosylmethionine) Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
Pharmaceuticals (Basel), 2025, 18(9)1395
J Oral Microbiol, 2024, 16(1):2292375
Nat Metab, 2023, 10.1038/s42255-023-00861-4
S6010 Sodium L-lactate Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent.
Cell Commun Signal, 2025, 23(1):104
J Transl Med, 2025, 23(1):69
EMBO Rep, 2024, 25(12):5599-5619
S1031 3-Hydroxybutyric acid (BHB acid) 3-Hydroxybutyric acid (BHB) is a small molecule metabolite that is elevated in type I diabetes.
BMC Med, 2022, 20(1):148
S1466 Calcitriol (1,25-Dihydroxyvitamin D3) Calcitriol is a nonselective vitamin D receptor activator/agonist (VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity (IC50=0.4 nM) than the selective VDRA paricalcitol. Solutions are unstable and should be fresh-prepared.
Cell Commun Signal, 2025, 23(1):104
Cancer Sci, 2025, 116(7):1871-1882
Cureus, 2025, 17(4):e82934
Verified customer review of Calcitriol (1,25-Dihydroxyvitamin D3)
S2298 Fisetin Fisetin (Fustel) is a potent Sirtuin activating compound (STAC) and an agent that modulates sirtuins.
Sci Adv, 2025, 11(17):eads1875
Mol Cancer, 2024, 23(1):222
Cell Death Dis, 2024, 15(8):608
Verified customer review of Fisetin
S1236 Leucovorin Calcium Pentahydrate (Folinic acid) Leucovorin (Folinic acid) Calcium Pentahydrate is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favouring folic acid inhibition.Solutions are unstable and should be fresh-prepared.
J Exp Clin Cancer Res, 2025, 44(1):13
iScience, 2024, 27(10):110862
Cell Rep Med, 2023, 4(10):101200