Antiviral Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| E0153 | Lithium Chloride |
Lithium Chloride (LiCl) inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats. Lithium Chloride can be used to induce animal models of Chronic Epilepsy. |
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| S6814 | GS-441524 | GS-441524, a molecular precursor to a pharmacologically active nucleoside triphosphate molecule, is a potent inhibitor of feline infectious peritonitis virus (FIPV) with EC50 of 0.78 μM. |
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| S9063 | Harringtonine | Harringtonine is a natural cephalotaxine alkaloid that inhibits protein biosynthesis. It also exhibits antiviral and anticancer activities. |
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| S8750 | NGI-1 | NGI-1 is an aminobenzamide-sulfonamide compound that targets both oligosaccharyltransferase (OST) isoforms and therefore may exhibit Antiviral activity against flaviviruses. |
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| S9669 | U18666A | U18666A (U18) is an inhibitor of intra-cellular cholesterol transport that inhibits dengue virus entry and replication. |
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| S5952 | Baloxavir marboxil | Baloxavir marboxil (S-033188), a cap-endonuclease inhibitor, is an Antiviral drug. |
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| S9303 | Saikosaponin B2 | Saikosaponin B2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry. |
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| S2764 | DTNB | DTNB (Ellman’s Reag, Ellmans Reagenz, 5,5′-Dithiobis(2-nitrobenzoic acid), 5,5′-Dithiobis-2-nitrobenzoesäure) is a non-fluorescent probe used to quantify the number or concentration of thiol groups in a sample. This compound is also an allosteric inhibitor of dengue virus protease (NS2B-NS3pro) and Streptomyces proteases. |
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| E0150 | Carrageenan |
Carrageenan (kappa-Carrageenan) is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. This compound shows anticoagulant activity, antithrombotic activity, Antiviral activity, anti-tumour activity and immunomodulatory activity. It can be used to induce animal models of Prostatitis. |
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| E1422 | (+)-JNJ-A07 | (+)-JNJ-A07 is a highly potent inhibitor of Dengue virus (DENV) with an EC50 of 0.1 nM in the DENV-2 strain (16681) in Vero cells. It exhibits antiviral activity by preventing the formation of the viral replication complex through blocking the interaction between two viral proteins, NS3 and NS4B. | ||
| S5554 | Lanatoside C | Lanatoside C is a cardiac glycoside with antiviral and anti-tumour activity. This compound induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signalling pathways. | ||
| E0336 | CBS1117 | CBS1117 is a virus entry inhibitor with an IC50 of 70 nM for influenza A virus, A/Puerto Rico/8/34 (H1N1), also interferes with the haemagglutinin (HA)-mediated fusion process. | ||
| S6867 | Glyceryl monocaprate (Monocaprin) | Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans. | ||
| E0110 | Baloxavir | Baloxavir (Baloxavir acid, S-033447) is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor with an IC50 of 2.5 nM. This compound inhibits viral RNA transcription via selective inhibition of CEN activity. | ||
| S3356 | Phosphonoacetic acid |
Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. This compound exhibits anti-viral activities. |
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| E0942 | BVDV IN-1 | BVDV IN-1 is a non-nucleoside inhibitor of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. | ||
| E0066 | Theaflavin 3,3'-digallate | Theaflavin 3,3'-digallate (TF-3, ZP10, TFDG) is a black tea polyphenol and acts as a potent Zika virus (ZIKV) protease inhibitor with an IC50 of 2.3 μM. | ||
| S0163 | Qstatin | QStatin is a potent and selective inhibitor of SmcR (V. harveyi LuxR homologue) with an EC50 of 208.9 nM, binding tightly to SmcR and changes the flexibility of the protein, thereby altering its transcription regulatory activity, which can be a sustainable antivibriosis agent useful in aquacultures. | ||
| E0835 | CID-1517823 | CID-1517823 (ML328) is a potent and selective inhibitor of bacterial AddAB and RecBCD helicase-nucleases, with IC50s of 1.0 and 4.8 μM. | ||
| S6865 | Alisporivir | Alisporivir (Debio-025) is a cyclophilin inhibitor molecule with potent anti-hepatitis C virus (HCV) activity. | ||
| S1102 | U0126-EtOH | U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM in cell-free assays, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. |
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| S1623 | N-Acetylcysteine (NAC chemical, N-Acetyl-L-Cysteine) | Acetylcysteine (N-acetyl-l-cysteine, NAC, N-acetylcysteine) is a ROS (reactive oxygen species) inhibitor that antagonises the activity of proteasome inhibitors. It is also a tumor necrosis factor production inhibitor. Acetylcysteine (N-acetyl-l-cysteine) suppresses TNF-induced NF-κB activation through inhibition of IκB kinases. Acetylcysteine (N-acetyl-l-cysteine) induces apoptosis via the mitochondria-dependent pathway. Acetylcysteine (N-acetyl-l-cysteine) inhibits ferroptosis and virus replication.Solutions are unstable and should be fresh-prepared. |
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| S7775 | Emricasan (IDN-6556) | Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor. Emricasan is an inhibitor of Zika virus infection. |
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| S1537 | Vadimezan (DMXAA) | Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. It is also a STING agonist with potential antineoplastic activity, potently inducing IFN-β but relatively low TNF-α expression in vitro. This compound has antiviral activity. Phase 3. |
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| S2713 | Geldanamycin (NSC 122750) | Geldanamycin is a naturally existing HSP90 inhibitor with Kd of 1.2 μM, specifically disrupts glucocorticoid receptor (GR)/HSP association. Geldanamycin attenuates virus infection-induced ALI (acute lung injury)/ARDS (acute respiratory distress syndrome) by reducing the host's inflammatory responses. |
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| S2239 | Tubacin | Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM in a cell-free assay, approximately 350-fold selectivity over HDAC1. This compound reduces the replication of the Japanese Encephalitis Virus via the decrease of viral RNA synthesis. |
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| S1401 | Tenofovir | Tenofovir (GS-1278) blocks reverse transcriptase and hepatitis B virus infections. |
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| S4879 | Tenofovir hydrate | Tenofovir (GS-1278) hydrate blocks reverse transcriptase and hepatitis B virus infections. |
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| E0365 | Fucoidan |
Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, Antiviral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc. |
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| S9926 | ML-SA1 |
ML-SA1 (Mucolipin synthetic agonist 1) is an activator of TRPML channels. This compound also inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 values of this chemical against DENV2 RNA and ZIKV RNA are 8.93 μM and 52.99 μM, respectively. It induces autophagy. It can be used for the research of broad-spectrum antiviral. |
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| E0010 | Hypocrellin A | Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signalling pathways. This compound is also a selective and potent inhibitor of PKC. |
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