Angiotensin Receptor Agonists

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
E4616	Buloxibutid	Buloxibutid (AT2 Agonist C21) is a selective agonist of angiotensin II type 2 receptor (AT2R) with a Ki value of 0.4 nM for the AT2 receptor and a Ki >10 µM for the AT1 receptor. Its treatment significantly reduces vascular remodelling, improves hemodynamics, and decreases pulmonary collagen deposition in the Sugen-Hypoxia model of pulmonary hypertension.
E1060	AVE 0991	AVE 0991 is a potent, orally active, non-peptide selective agonist of the Mas receptor (MasR), functioning as a stable mimic of angiotensin-(1–7) [Ang-(1–7)]. It demonstrates high-affinity binding to endothelial MasR with an IC50 of 21 nmol/L in bovine aortic endothelial cell membranes and evokes endothelial effects similar to Ang-(1–7), including robust nitric oxide (NO) release with minimal superoxide (O2−) production.