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AVE 0991 Angiotensin Receptor agonist

Name: AVE 0991
Brand: Selleck Chemicals
SKU: E1060
Rating: 5 (1 reviews)

Cat.No.E1060

AVE 0991 is a potent, orally active, non-peptide selective agonist of the Mas receptor (MasR), functioning as a stable mimic of angiotensin-(1–7) [Ang-(1–7)]. It demonstrates high-affinity binding to endothelial MasR with an IC50 of 21 nmol/L in bovine aortic endothelial cell membranes and evokes endothelial effects similar to Ang-(1–7), including robust nitric oxide (NO) release with minimal superoxide (O2−) production.

Chemical Structure

Molecular Weight: 580.72

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Quality Control

Batch: E106001 DMSO]100 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false Purity: 98.05%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

98.05

Related Targets	CXCR Hedgehog/Smoothened PKA Adrenergic Receptor AChR 5-HT Receptor Histamine Receptor Dopamine Receptor Ras KRas
Other Angiotensin Receptor Inhibitors	PD123319 ML221 A-779 Fimasartan Olodanrigan (EMA401) Buloxibutid

Chemical Information, Storage & Stability

Molecular Weight	580.72	Formula	C₂₉H₃₂N₄O₅S₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	304462-19-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (172.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 3 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/12468568/

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