Sigma Receptor Agonists

Cat.No.	Product Name	Information	Product Use Citations
S6950	PRE-084 hydrochloride	PRE-084 hydrochloride (HCl) is a potent, selective sigma-1 receptor (σ1, S1R) agonist with IC50 of 44 nM in the sigma receptor assay.	Free Radic Biol Med, 2025, 226:96-108
E7191	Ditolylguanidine	Ditolylguanidine (1,3-di-o-tolylguanidine) is a non-selective agonist of Sigma Receptor (σ receptor) with high affinity Ki values of 69 nM and 21 nM for σ1 and σ2 receptors, respectively. It effectively inhibits the growth of small cell lung cancer cells and can be used for the research of lung cancer.	HIV Med, 2025, 26(2):285-294
S6756	Siramesine HCl	Siramesine (Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively.	J Transl Med, 2025, 23(1):780
S0295	Anavex 2-73 HCl	Anavex 2-73 (Blarcamesine, AVex-73, AE-37), an aminotetrahydrofuran derivative, is a mixed muscarinic and sigma-1/σ₁ Receptor agonist with IC50 of 0.86 μM.
S0869	Carbetapentane	Carbetapentane (Pentoxyverine, CB) is an antitussive anticonvulsant nonselective sigma-1 (σ1) agonist.
S6561	4-IBP	4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM).
E7744	Siramesine	Siramesine (Lu 28-179) is a potent agonist of sigma-2 receptor(σ1R) with an IC50 of 0.12 nM, exhibiting 140-fold selectivity over sigma-1 receptors. It shows strong anxiolytic effects and induces cancer cell death, highlighting its potential anticancer activity.
S2917	Cutamesine Dihydrochloride	Cutamesine dihydrochloride (SA4503 dihydrochloride, AGY94806 dihydrochloride) is a potent Sigma-1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.