Home Metabolism Lipoxygenase

Lipoxygenase

Other Metabolism Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S1396 Resveratrol (trans-Resveratrol) Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.
Aging Cell, 2025, e70075
Biomed Pharmacother, 2025, 190:118393
Breast Cancer Res, 2025, 27(1):186
Verified customer review of Resveratrol (trans-Resveratrol)
S1443 Zileuton Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma. This compound induces apoptosis while inhibits ferroptosis.
Nat Commun, 2024, 15(1):8663
J Transl Med, 2023, 21(1):923
Cancer Sci, 2023, 10.1111/cas.15994
Verified customer review of Zileuton
S6557 ML355 ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases.
Vaccines (Basel), 2023, 11(2)205
Redox Biol, 2022, 55:102421
Oncogenesis, 2021, 10(2):15
S1137 Malotilate Malotilate (NKK105) is a drug used for the treatment of liver cirrhosis. This compound is a liver protein Metabolism improved compound, which selectively inhibit the 5-lipoxygenase.
J Cachexia Sarcopenia Muscle, 2022, 13(6):3062-3077
S3984 Nordihydroguaiaretic acid (NDGA) Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the evergreen desert shrub, Larrea tridentata (Sesse and Moc. ex DC) Coville (creosote bush). It is a recognised inhibitor of lipoxygenase (LOX) and has antioxidant and free radical scavenging properties. Nordihydroguaiaretic acid (NDGA) is a cytotoxic insulin-like growth factor-I receptor (IGF-1R)/HER2 inhibitor and induces apoptosis.
Gut Microbes, 2025, 17(1):2518338
S6956 PD146176

PD146176 (NSC168807) is a potent inhibitor of 15-Lipoxygenase (15-LO) with Ki of 197 nM for rabbit reticulocyte 15-LO.
Br J Cancer, 2023, 129(4):601-611
S9378 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
Medical University of Bialystok, 2022, Vol. 79 No. 6 pp. 835-840, 2022
S9024 AKBA (3-O-Acetyl-11-keto-β-boswellic acid) AKBA (3-O-Acetyl-11-keto-β-boswellic acid), the major active ingredient of the gum resin from Boswellia serrata and Boswellia carteri Birdw., exerts anti-inflammatory therapeutic effects and noncompetitively inhibits 5-lipoxygenase, topoisomerase, and leukocyte elastase.
Nat Cancer, 2022, 3(5):629-648
S9421 Demethylnobiletin Demethylnobiletin (5-Demethylnobiletin) is a unique flavonoid found in citrus fruits with potential chemopreventive effects against human cancers. This compound is a direct inhibitor of 5-LOX with IC50 of 0.1 μM, without affecting the expression of COX-2. It has anti-inflammatory activity, inhibits leukotriene B 4(LTB4) formation in rat neutrophils and elastase release in human neutrophils with IC50 of 0.35 μM.
Front Oncol, 2023, 13:1143664
S4711 Esculetin Esculetin (Cichorigenin, Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-oedema, anti-inflammatory and anti-tumour effects. It inhibits lipoxygenases (LOs).
Cancer Lett, 2021, S0304-3835(21)00436-5