Home Cell Cycle LIM kinase

LIM kinase

Other Cell Cycle Inhibitors

CDK ROCK Wee1 Aurora Kinase Chk PLK APC MPS1 Rho Myc
Cat.No. Product Name Information Product Use Citations Product Validations
S0185 BMS-5 BMS-5 (LIMKi 3) is a potent inhibitor of LIM kinases (LIMK) with IC50 of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
Adv Sci (Weinh), 2025, 12(29):e03223
Leukemia, 2025, 10.1038/s41375-025-02729-w
S6498 T56-LIMKi T56-LIMKi is a selective inhibitor of LIMK2.
S6837 R-10015 R-10015 is a potent, selective inhibitor of LIM domain kinase (LIMK) with IC50 of 38 nM for human LIMK1. This compound binds to the ATP-binding pocket and acts as a broad-spectrum antiviral compound for HIV infection.
S6836 TH-257 TH-257 is a potent and exquisitely selective LIM kinase (LIMK) inhibitor with IC50 of 84 nM and 39 nM for LIMK1 and LIMK2, respectively.
E1724 CRT-0105446 CRT 0105446 (compound 22d) is a potent inhibitor of LIMK1 with an IC50 of 8 nM. It can inhibit the growth of MCF-7 breast cancer cells and the invasion of MDA-MB-231 cells by reducing the expression of phosphorylated cofilin.