YAP inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| E1490 | IAG933 | IAG933 (YAP-TEAD-IN-3) is a small molecule and acts as a YAP/TAZ-TEAD inhibitor. It also inhibits NCI-H2052 and can be used in research of tumour invasion and metastatic spread of solid tumours. |
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| E1563 | GNE-7883 | GNE-7883 is a potent and allosteric small-molecule inhibitor of pan-TEAD, that allosterically blocks the interactions between YAP/TAZ and all human TEAD paralogs through binding to the TEAD lipid pocket. It effectively reduces chromatin accessibility at TEAD motifs, suppresses cell proliferation in a variety of cell line models and achieves strong antitumor efficacy in vivo. Furthermore, it effectively overcomes KRAS G12C inhibitor resistance. | ||
| S1786 | Verteporfin | Verteporfin is a small molecule that inhibits TEAD–YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin. Verteporfin is an autophagy inhibitor. Verteporfin inhibits cell proliferation and induces apoptosis. |
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| E1061 | TRULI (Lats-IN-1) | TRULI inhibits both Lats1 and Lats2 with an IC50 of 0.2 nM, suppresses YAP phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear. |
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| S8184 | Cytochalasin D | Cytochalasin D (Zygosporin A, NSC 209835) is a potent actin polymerization inhibitor derived from fungus. Cytochalasin D inhibits actin filament dynamics in cells. It induces phosphorylation and cytoplasmic retention of Yap. |
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| S8661 | CA3 (CIL56) | CA3 (CIL56) has potent inhibitory effects on YAP1/Tead transcriptional activity and primarily targets YAP1 high and therapy-resistant esophageal adenocarcinoma cells endowed with CSC properties. CA3(CIL56) induces Ferroptosis and iron-dependent reactive oxygen species (ROS). |
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| E1314 | TDI-011536 | TDI-011536 is a potent Lats kinase inhibitor that interrupts Hippo-Yap signalling and promotes proliferation of lesioned cardiac muscle cells. |
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| S8554 | Super-TDU | Super-TDU is an inhibitory peptide targeting YAP-TEADs interaction. |
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| S8951 | TED-347 | TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD⋅Yap protein-protein interaction. This compound inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM. |
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| S9861 | PY-60 | PY-60 is a small-molecule activator of the transcriptional coactivator Yes-associated protein (YAP) with EC50 of 1.6 µM, which acts by inhibiting a central scaffolding protein in the Hippo pathway, Annexin A2. It promotes the regenerative repair of cutaneous wounds in pig and human models. |
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