Home Metabolism Phospholipase (e.g. PLA)

Phospholipase (e.g. PLA) Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S0053 CAY10593 (VU0155069) CAY10593 (VU0155069) is a selective phospholipase D1 (PLD1) antagonist that impairs human P2X7 acivation.
Free Radic Biol Med, 2021, S0891-5849(21)00821-2
S0982 m-3M3FBS m-3M3FBS is a potent activator of phospholipase C (PLC) that stimulates a transient intracellular calcium concentration increase in neutrophils. This compound induces apoptosis in monocytic leukaemia cells.
Pharmaceuticals (Basel), 2022, 15(12)1444
S6522 ST 271 ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.
S9478 Trans-4-Phenyl-3-buten-2-one Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). This compound is used as a flavouring agent, a fragrance and a bacterial metabolite.
S6564 ML348 ML348 (GNF-Pf-1127) is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.
E1116 AACOCF3 AACOCF3 (Arachidonyl trifluoromethyl ketone) is an inhibitor of cytosolic phospholipase A2 (cPLA2) and calcium-independent phospholipase A2(iPLA2) with IC50 of 1.5 μM and 6.0 μM, respectively. It inhibits aortic osteoinductive signalling and vascular calcification in the cholecalciferol-overload mouse model.
E1765 U-73343 U-73343 is an inactive analog of U-73122 that acts downstream of phospholipase C and inhibits receptor-mediated phospholipase D (PLD) activation in CHO-CCK_A cells.
S5913 Cambinol Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).
E8148 BAPTA BAPTA is a Ca²⁺ chelator and an inhibitor of phospholipase C (PLC) with an IC50 of 7.0 mM and exhibits high Ca²⁺ selectivity, minimal pH dependence, and a fast binding rate. Its rapid Ca²⁺ buffering capacity makes it ideal for studying Ca²⁺ release from intracellular stores or influx through Ca²⁺ channels.
E8206 CAY10650 CAY10650 is a potent inhibitor of cytosolic phospholipase A2α (cPLA2α), with an IC50 of 12 nM. It exhibits anti-inflammatory effects in a murine contact dermatitis model.
S4107 Clofazimine Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action of this compound include intercalation of this chemical with bacterial DNA and increasing levels of cellular phospholipase A2.
Viruses, 2024, 16(4)640
Cell Rep Methods, 2023, 3(10):100599
Blood, 2022, blood.2021014304
S0766 RHC 80267 RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL, DAG lipase) with IC50 of 4 μM for cholinesterase activity. This compound inhibits cyclooxygenase (COX) activity, phospholipase C (PLC) activity and the hydrolysis of phosphatidylcholine (PC).