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Cambinol Phospholipase (e.g. PLA) inhibitor

Name: Cambinol
Brand: Selleck Chemicals
SKU: S5913
Rating: 5 (1 reviews)

Cat.No.S5913

Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).

Chemical Structure

Molecular Weight: 360.43

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Quality Control

Batch: S591301 DMSO]21 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.73%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.73

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Phospholipase (e.g. PLA) Inhibitors	Varespladib (LY315920) Darapladib (SB-480848) GW4869 U-73122 Tanshinone I Quinacrine 2HCl (E/Z)-Polydatin Trigonelline Melittin FIPI

Chemical Information, Storage & Stability

Molecular Weight	360.43	Formula	C₂₁H₁₆N₂O₂S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	14513-15-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C1=CC=C(C=C1)C2=C(C(=O)NC(=S)N2)CC3=C(C=CC4=CC=CC=C43)O

Solubility

In vitro
Batch:

DMSO : 21 mg/mL (58.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	nSMase2 (Cell-free assay) 7 μM(Ki)
In vitro	Cambinol decreases tumor necrosis factor-α or interleukin-1 β-induced increases of ceramide and cell death in primary neurons. This compound is an inhibitor of the NAD-dependent deacetylase activity of sirtuin, human silent information regulator type 1/2 (SIRT1/2), with IC50 values of 56 μM and 59 μM for SIRT1 and SIRT2, respectively. It induces apoptosis in BCL6-expressing Burkitt lymphoma cell lines. This chemical is approximately a 10-fold more potent human nSMase2 inhibitor compared to SIRT1/2. It is a potent inhibitor of acidic pHe-mediated anterograde lysosome trafficking.
In vivo	Cambinol is well tolerated in mice and has potent antitumor activity in vivo.
References	[1] https://pubmed.ncbi.nlm.nih.gov/26010541/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668693/

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