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SRPIN340 Serine/threonin kinase inhibitor

Name: SRPIN340
Brand: Selleck Chemicals
SKU: S7270
Rating: 5 (5 reviews)

Cat.No.S7270

SRPIN340 is a selective SRPK inhibitor with K_i of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases.

Chemical Structure

Molecular Weight: 349.35

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Quality Control

Batch: S727001 DMSO]70 mg/mL]false]Ethanol]70 mg/mL]false]Water]Insoluble]false Purity: 99.9%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.9

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Serine/threonin kinase Inhibitors	WNK463 GCN2iB Benzamidine HCl SPHINX31 SGC-GAK-1 ML281 BAY-1816032 DCLK1-IN-1 ZT-12-037-01 Luvixasertib (CFI-402257)

Chemical Information, Storage & Stability

Molecular Weight	349.35	Formula	C₁₈H₁₈F₃N₃O	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	218156-96-8	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3

Solubility

In vitro
Batch:

DMSO : 70 mg/mL (200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 70 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Features	The only specific SRPK1 and SRPK2 inhibitor. Potential use in congenital diseases and viral diseases including HIV, HCV and HBV.
Targets/IC₅₀/Ki	SRPK1 0.89 μM(Ki)
In vitro	SRPIN340 inhibits SR phosphorylation by SRPK in Flp-In293 cells and promotes degradation of SRp75 in a dose-dependent manner, which subsequently inhibits HIV production. This compound dose (5 mg/mL) produces no abnormalities in chromosomal structure and chromosome number of CHO cells. It suppresses in a dose-dependent fashion expression of a HCV subgenomic replicon and replication of the HCV-JFH1 clone in vitro.
In vivo	SRPIN340 inhibits CNV formation in a dose-dependent manner in vivo. This compound significantly decreases the protein levels of VEGF, MCP-1, ICAM-1, and consequently inhibits macrophage infiltration.
References	[1] https://pubmed.ncbi.nlm.nih.gov/16840555/ [2] https://pubmed.ncbi.nlm.nih.gov/20498328/ [3] https://pubmed.ncbi.nlm.nih.gov/23559848/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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