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Loganin BACE inhibitor

Name: Loganin
Brand: Selleck Chemicals
SKU: S3835
Rating: 5 (1 reviews)

Cat.No.S3835

Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. This compound is a non-competitive inhibitor of BACE1 with IC50 of 47.97 μM and also inhibits AChE and BChE with IC50 values of 3.95 μM and 33.02 μM, respectively.

Chemical Structure

Molecular Weight: 390.38

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Quality Control

Batch: S383501 DMSO]78 mg/mL]false]]]false]]]false Purity: 99.94%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.94

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other BACE Inhibitors	Verubecestat (MK-8931) LY2811376 LY2886721 Verubecestat (MK-8931) Trifluoroacetate AZD3839 Lanabecestat (AZD3293) Elenbecestat LX2343

Chemical Information, Storage & Stability

Molecular Weight	390.38	Formula	C₁₇H₂₆O₁₀	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	18524-94-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Loganoside			Smiles	CC1C(CC2C1C(OC=C2C(=O)OC)OC3C(C(C(C(O3)CO)O)O)O)O

Solubility

In vitro
Batch:

DMSO : 78 mg/mL (199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	AChE (Cell-free assay) 3.95 μM BChE (Cell-free assay) 33.02 μM BACE1 (Cell-free assay) 47.97 μM
In vitro	In SMN-deficient NSC34 cells, loganin increases cell viability, neurite length, and expressions of SMN, Gemin2, SMN-Gemin2 complex, p-Akt, p-GSK-3, p-CREB, BDNF and Bcl-2. This compound attenuates H2O2-induced neuronal damage via suppressing MAPKs signals in SH-SY5Y cells. It may directly promote the differentiation and inhibit the apoptosis of MC3T3-E1 cells and indirectly reduce bone resorption. This chemical could directly enhance the function of osteoblasts and elevate their survival rate, indirectly inhibit the function of osteoclasts and reduce the number of osteoclasts via RANKL from osteoblasts.
In vivo	Loganin provides benefits to SMA (spinal muscular atrophy) therapeutics via improving SMN (survival motor neuron) restoration, muscle strength and body weight. In type 2 diabetes mice, this compound not only lowers blood glucose but also attenuates hyperglycemia-induced inflammation, oxidative stress and apoptosis. It improves spatial memory in streptozotocin-induced diabetic rats and exhibits antiamnesic activity in scopolamine-treated mice via acetylcholinesterase inhibition.
References	[1] https://pubmed.ncbi.nlm.nih.gov/27106028/ [2] https://pubmed.ncbi.nlm.nih.gov/27241020/ [3] https://pubmed.ncbi.nlm.nih.gov/20966881/

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Handling Instructions

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