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(+)-Catechin Antioxidant chemical

Name: (+)-Catechin
Brand: Selleck Chemicals
SKU: S4722
Rating: 5 (3 reviews)

Cat.No.S4722

(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an Antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.

Chemical Structure

Molecular Weight: 290.27

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Quality Control

Batch: Purity: 99.79%

99.79

Related Targets	PD-1/PD-L1 CXCR STING AhR Immunology & Inflammation related CD markers Interleukins Anti-infection COX Histamine Receptor
Other Antioxidant Inhibitors	Elamipretide (SS-31, MTP-131) Tangeretin Silymarin Oleuropein (-)Epicatechin Hydroxygenkwanin Syringic acid Cocoa Extract Sesamol Flavanone

Chemical Information, Storage & Stability

Molecular Weight	290.27	Formula	C₁₅H₁₄O₆	Storage (From the date of receipt)	3 years -20°C powder (seal)
CAS No.	154-23-4	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Cianidanol, Catechinic acid, Catechuic acid, Catechin			Smiles	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

Solubility

In vitro
Batch:

DMSO : 58 mg/mL (199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 58 mg/mL

Water : 1.8 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	COX-1 (Cell-based assay) 80 μM COX-2 (Cell-based assay) 130 μM
In vitro	The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 40 μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 µM and 130 μM.
In vivo	Dietary catechin significantly delayed tumour onset. Continued intake of catechin, a potential Antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence. (+)-Catechin inhibits intestinal tumour formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse.
References	[1] http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000300009 [2] http://www.nature.com/articles/srep23077 [3] https://pubmed.ncbi.nlm.nih.gov/9741297/ [4] https://pubmed.ncbi.nlm.nih.gov/8187052/ [5] https://pubmed.ncbi.nlm.nih.gov/12324302/ [6] https://pubmed.ncbi.nlm.nih.gov/16957869/ [7] http://cancerres.aacrjournals.org/content/canres/61/1/118.full.pdf

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