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Mitochondrial Metabolism Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S6036 ER-000444793 ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening with IC50 of 2.8 μM.
S2592 Emapunil (AC 5216) Emapunil (AC-5216, 18 kiloDalton Translocator Protein, XBD173) is a novel mitochondrial benzodiazepine receptor/translocator protein (MBR/TSPO) ligand. This compound shows high affinity for MBRs prepared from rat whole brain with Ki of 0.297 nM and IC50 of 3.04 nM and 2.73 nM at rat glioma cells and human glioma cells, respectively.
E0032 Olesoxime (TRO 19622)

Olesoxime (TRO19622) is a novel, orally active and CNS-penetrant mitochondrial-targeted neuroprotective compound.
E1888New NIM811 ((Melle-4)cyclosporin) NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally administered dual inhibitor targeting mitochondrial permeability transition and cyclophilin, demonstrating strong in vitro antiviral activity against hepatitis C virus (HCV).
S3593 Rhodamine 6G Rhodamine 6G (R6G, Basic Red 1, Rhodamine 590) is a fluorescence tracer that binds to mitochondria, thus reducing the intact mitochondria number and inhibiting mitochondrial metabolic activity.
E1252 MitoPQ MitoPQ (MitoParaquat), a mitochondria-targeted redox cycler, enables the selective generation of superoxide within mitochondria and is a useful tool to investigate the many roles of mitochondrial superoxide in pathology and redox signaling in cells and in vivo.
S7309 BAY 87-2243 BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. This compound inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and Ferroptosis. It exerts antitumor activity. Phase 1.
Cancer Sci, 2025, 116(8):2113-2124
Cancer Sci, 2025, 10.1111/cas.70102
Hum Reprod Open, 2024, 2024(1):hoae002
Verified customer review of BAY 87-2243
S7009 LCL161 LCL-161, a small molecule second mitochondrial activator of caspase (SMAC) mimetic, potently binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP).
Immunity, 2025, 58(4):961-979.e8
Nat Commun, 2025, 16(1):4919
EMBO Mol Med, 2025, 10.1038/s44321-025-00201-x
Verified customer review of LCL161
S3296 Hispidulin Hispidulin (Dinatin), an active natural ingredient in a number of traditional Chinese medicinal herbs, exhibits inhibitory activity against the oncogenic protein kinase Pim-1 with IC50 of 2.71 μM. This compound induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. It exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signalling pathway.
Evid Based Complement Alternat Med, 2023, 2023:9428241
S8943 VLX600 VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS), potentiates the effect of radiation in tumour spheroids in a synergistic manner. This compound shows enhanced cytotoxic activity under conditions of nutrient starvation. It induces autophagy and mitochondrial inhibition with antitumour activity.
Cancers (Basel), 2022, 14(13)3225
S0411 BAM 15 BAM 15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischaemic-reperfusion injury and cold-induced microtubule damage. This compound is also a potent AMPK activator. It attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
Neuroscience, 2012, 223:238-45
S3264 Atractyloside potassium salt Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. This compound inhibits chloride channels from mitochondrial membranes of rat heart.
S0012 E260 E260 (Fer and FerT inhibitor E260) is a Fer kinase and FerT inhibitor that selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation, and onset of energy-consuming autophagy which decreases the cellular ATP level.
S9925 Imeglimin (EMD 387008) Hydrochloride

Imeglimin (EMD 387008, IMEG, PXL 008, RVT-1501) Hydrochloride is a new class of oral glucose-lowering agents. Imeglimin normalises glucose tolerance and insulin sensitivity by preserving mitochondrial function from oxidative stress and favouring lipid oxidation in liver of HFHSD mice.