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Mitochondrial Metabolism Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2968 CTPI-2 CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with KD of 3.5 μM. This compound is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs).
Cancers (Basel), 2024, 16(21)3606
Res Sq, 2024, rs.3.rs-5278203
J Immunol, 2022, 208(5):1085-1098
S0767 NL-1 The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of this compound binding for [3H]-rosiglitazone is 0.9 μM and the Ki for this chemical site 1 and site 2 was 4.78 and 2.77, respectively.
J Transl Med, 2024, 22(1):593
E1823 Ninerafaxstat trihydrochloride Ninerafaxstat trihydrochloride (MB-1018972 trihydrochloride, IMB-101 trihydrochloride) acts as a competitive inhibitor of 3-ketoacyl-CoA thiolase (3-KAT) to partially suppress fatty acid oxidation. It is an orally active cardiac mitochondrial drug that restores myocardial energy homeostasis. This compound regulates myocardial substrate utilization and improves cardiac efficiency. It is also used in research of cardiovascular diseases.
E1583 MFI8 MFI8 is a small molecule inhibitor of mitofusin-1 (MFN1) and mitofusin-2 (MFN2). It significantly reduces mitochondrial aspect ratio, inhibiting mitochondrial fusion and subsequently promoting mitochondrial fission and can be used in research on disorders with impaired mitochondrial dynamics.
S6268 4-Pentenoic acid 4-Pentenoic acid (Allylacetic acid, 3-vinylpropionic acid, 4-penten-1-oic acid), a flavouring ingredient, is used to inhibit fatty acid oxidation in rat heart mitochondria.
S6036 ER-000444793 ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening with IC50 of 2.8 μM.
E1888New NIM811 ((Melle-4)cyclosporin) NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally administered dual inhibitor targeting mitochondrial permeability transition and cyclophilin, demonstrating strong in vitro antiviral activity against hepatitis C virus (HCV).
S3593 Rhodamine 6G Rhodamine 6G (R6G, Basic Red 1, Rhodamine 590) is a fluorescence tracer that binds to mitochondria, thus reducing the intact mitochondria number and inhibiting mitochondrial metabolic activity.
S7309 BAY 87-2243 BAY 87-2243 is a potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. This compound inhibits mitochondrial complex I activity, thus triggering a mitophagy-dependent ROS increase leading to necroptosis and Ferroptosis. It exerts antitumor activity. Phase 1.
Cancer Sci, 2025, 116(8):2113-2124
Cancer Sci, 2025, 10.1111/cas.70102
Hum Reprod Open, 2024, 2024(1):hoae002
Verified customer review of BAY 87-2243
S8943 VLX600 VLX600 is a novel iron-chelating inhibitor of oxidative phosphorylation (OXPHOS), potentiates the effect of radiation in tumour spheroids in a synergistic manner. This compound shows enhanced cytotoxic activity under conditions of nutrient starvation. It induces autophagy and mitochondrial inhibition with antitumour activity.
Cancers (Basel), 2022, 14(13)3225
S3264 Atractyloside potassium salt Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. This compound inhibits chloride channels from mitochondrial membranes of rat heart.