HBV Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S0285	Bay 41-4109 racemate	BAY 41-4109 racemate (BAY41-4109 Racemic) is a mixture of R-isomer of BAY 41-4109 and S-isomer of BAY 41-4109. BAY 41-4109 an antiviral compound that inhibits human hepatitis B virus (HBV) with IC50 of 53 nM.	Nat Commun, 2021, 12(1):2114
E0094	Morphothiadin	Morphothiadin (GLS4) is a potent inhibitor on the replication of both wild-type and adefovir-resistant Hepatitis B virus (HBV) with an IC50 of 12 nM. This compound, a nucleoside analogs that target the virus polymerase, can block the HBV replication cycle and HBV-associated chronic liver diseases.	Viruses, 2024, 16(3)323
S4199	Antazoline HCl	Antazoline hydrochloride (Phenazoline hydrochloride) is a first-generation antihistamine with anticholinergic properties and is commonly used to relieve nasal congestion and in eye drops. Antazoline hydrochloride exhibits a significant inhibitory effect on HBV DNA in the Huh7 cells, with an EC50 of 2.349 μmol/L.
S0038	AB-423	AB-423, a member of the sulfamoylbenzamide (SBA) class of hepatitis B virus (HBV) capsid inhibitors, shows potent inhibition of HBV replication with EC50 of 0.08 μM - 0.27 μM and EC90 of 0.33 μM - 1.32 μM in cells. Phase 1.
E3309	Polygala Fallax Hemsl. Rhizome Extract	Polygala Fallax Hemsl. Rhizome Extract is drawn from the rhizome of Polygala Fallax Hemsl., which has effects on immune function, such as anti-stress, anti-inflammatory, blood activating, lipid regulating, and in vitro inhibition of hepatitis B virus.
S6729	Besifovir	Besifovir is novel and potent acyclic nucleotide phosphonate used to treat hepatitis B virus (HBV) infection.
S6453	Bicyclol	Bicyclol (SY-801) is a drug that can improve liver function and inhibit HBV replication.
S1704	Emtricitabine (FTC)	Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor, and its intracellular half-life is 39 h.	Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317 HIV Med, 2025, 26(2):285-294 Immunity, 2024, 57(12):2928-2944.e6
S8627	OSS_128167	OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. This compound has an anti-viral effect in HBV transcription and replication.	Front Immunol, 2024, 15:1402834 Sci Rep, 2024, 14(1):30924 Antioxidants (Basel), 2023, 12(3)714
E1758	Bersacapavir	Bersacapavir (JNJ-6379, JNJ-56136379) is a potent capsid assembly modulator (CAM) that accelerates capsid assembly and induces the formation of morphologically intact viral capsids devoid of genomic material. It inhibits HBV replication with an EC50 of 54 nM in HepG2.117 cells.
S5979	2',3'-Dideoxyadenosine	2',3'-Dideoxyadenosine (ddA, ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication.
E1243	Azvudine	Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).