Home GPCR & G Protein cAMP

cAMP Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S8283 SQ22536 SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. This compound can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.
J Cachexia Sarcopenia Muscle, 2025, 16(3):e13853
J Ethnopharmacol, 2025, 347:119679
FASEB J, 2025, 39(7):e70528
Verified customer review of SQ22536
S7499 ESI-09 ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.
Pharmacol Res, 2025, 211:107562
J Biol Chem, 2023, 299(6):104749
Gen Comp Endocrinol, 2023, 335:114232
Verified customer review of ESI-09
S4552 Bithionol Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.
iScience, 2023, 10.1016/j.isci.2023.106661
Cancer Lett, 2020, 479:100-111
Inflammation, 2019, 42(5):1530-1541
S8416 PACAP 6-38 acetate PACAP 6-38 acetate is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.
Front Immunol, 2021, 12:714244
S7500 HJC0350 HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.
J Mol Cell Biol, 2019, 11(5):395-407
S3382 ESI-05 ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. This compound inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation.
E6418New MDL12330A MDL12330A is an inhibitor of adenylyl cyclase that blocks vasopressin-induced short-circuit current (SCC). It also inhibits cAMP phosphodiesterase, which may mask its effect on adenylyl cyclase.
S8414 PACAP 1-27 Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
S6478 Fipexide hydrochloride Fipexide (hydrochloride) is a psychoactive drug of the piperazine class.
S0451 ST034307 ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM.
E6044 3-O-Methylquercetin 3-O-Methylquercetin is a flavone isolated from Rhamnus nakaharai Hayata (Rhamnaceae), an inhibitor of cAMP and cGMP-phosphodiesterases(PDE) with an IC50 of 13.8 μM and 14.3 μM respectively. It also inhibits β-secretase with an IC50 of 6.5 μM. It exhibits antiviral activity and has been used in folk medicine for constipation, inflammation, tumours, and asthma.
S6850 NE 52-QQ57 NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. This compound effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with this chemical significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signalling molecules, including tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
Exp Hematol Oncol, 2024, 13(1):13