Tyrosinase

Other Proteases Inhibitors

Proteasome HCV Protease HIV Protease Thrombin MMP Cysteine Protease Serine Protease Glutaminase PAD Neprilysin

Cat.No.	Product Name	Information	Product Use Citations
S1021	Dasatinib (BMS-354825)	Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.	Cancer Cell, 2025, S1535-6108(25)00070-4 Mil Med Res, 2025, 12(1):83 Nat Commun, 2025, 16(1):4069
S1005	Axitinib (AG-013736)	Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, respectively.	Cancer Cell, 2025, S1535-6108(25)00070-4 Chem Biol Interact, 2025, 418:111628 Development, 2025, 152(13)dev204684
S2375	Aloin (Barbaloin)	Aloin (Barbaloin), a natural anthracycline from Aloe vera, is a Tyrosinase inhibitor.	Cytotechnology, 2025, 77(4):137 Nat Prod Commun, 2023, 18(5): 1–11 Nan Fang Yi Ke Da Xue Xue Bao, 2023, 43(5):702-709
S2263	Arbutin	Arbutin (Uva, p-Arbutin, β-Arbutin) is a tyrosinase inhibitor with IC50 of 0.9 mM and 0.7 mM for Monophenolase and Diphenolase, respectively.	Transl Oncol, 2023, 35:101712 G3 (Bethesda), 2020, 4;10(5):1585-1597 Int J Mol Sci, 2017, 18(9)
S6237	2-Ketoglutaric acid (alpha-ketoglutarate)	2-Ketoglutaric acid (alpha-ketoglutarate) is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, it is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. This compound is a reversible inhibitor of tyrosinase.	Int J Biol Sci, 2021, 17(5):1250-1262 Front Cell Infect Microbiol, 2020, 10:599087
S3783	Echinacoside	Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. This compound, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. It also has a remarkable antiosteoporotic activity.	Antioxidants (Basel), 2023, 10.3390/antiox12111925 Naunyn Schmiedebergs Arch Pharmacol, 2020, 10.1007/s00210-020-02022-w
S9111	Isorhamnetin	Isorhamnetin (3-methylquercetin, 3'-Methoxyquercetin, Isorhamnetol), a natural flavonol aglycon, is a tyrosinase inhibitor and has antioxidant activity.	Front Pharmacol, 2023, 14:1290868 Anat Rec (Hoboken), 2020, 10.1002/ar.24506
S1652	Monobenzone	Monobenzone (Benoquin) is a compound used as a topical agent for medical depigmentation. It can specifically block tyrosinase.Monobenzone can be used to induce animal models of Vitiligo.	Front Genet, 2020, 11:1000
S4739	Oxyresveratrol	Oxyresveratrol (Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbene), a naturally occurring compound particularly found in Morus alba L., exhibits a potent inhibitory effect on dopa oxidase activity of Tyrosinase which catalyzes rate-limiting steps of melanin biosynthesis.	Int J Mol Sci, 2022, 23(23)15102
S5174	Kojic acid	Kojic acid is a Fungal metabolite that inhibits Tyrosinase with an IC50 value of 30.6 M for mushroom Tyrosinase. It is a synthetic intermediate used for production of food additives.	Int J Mol Sci, 2017, 18(9)
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