Home Proteases Glutaminase

Glutaminase Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S7655 Telaglenastat (CB-839) Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. It induces Autophagy and has antitumor activity. Phase 1.
Signal Transduct Target Ther, 2025, 10(1):271
Bone Res, 2025, 13(1):62
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
Verified customer review of Telaglenastat (CB-839)
S7753 BPTES BPTES is a potent and selective Glutaminase GLS1 (KGA) inhibitor with IC50 of 0.16 μM. It has no effect on glutamate dehydrogenase activity and causes only a very slight inhibition of γ-glutamyl transpeptidase activity.
Signal Transduct Target Ther, 2025, 10(1):27
Biomed Pharmacother, 2025, 191:118492
STAR Protoc, 2025, 6(1):103518
Verified customer review of BPTES
S6417 GK921 GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition.
J Immunol Res, 2021, 2021:4754454
E0373New LDN-27219 LDN-27219 is a potent, reversible, slow-binding inhibitor of Tissue transglutaminase (TGase), which exhibits IC50 of 0.6 μM against human hTGase. It likely binds at the GTP-binding or regulatory site rather than the enzyme’s active site. It lowers blood pressure and improves endothelium-dependent vasodilation in resistance arteries in an age-dependent manner.
S8778 UPGL00004 UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2.
S8998 IACS-6274 IACS-6274 (IPN60090), is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities.
E2365 Glutaminase C-IN-1 Glutaminase C-IN-1 is an allosteric inhibitor of Glutaminase C (GAC) that inhibits cancer cell growth without affecting their normal cellular counterparts.
E0134 L-Albizziin

L-Albizziin (L-alpha-amino-beta-ureidopropionic acid) is a potent inhibitor of glutamase. L-Albizziin interferes with the utilisation of L-glutamine by the Debaryomyces spp. enzyme probably in a competitive and reversible manner since L-Albizziin is also a substrate of the enzyme.