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Glucagon Receptor agonists/antagonists

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Cat.No. Product Name Information Product Use Citations Product Validations
S9697 Semaglutide Semaglutide is an oral agonist of glucagon-like peptide-1 receptor (GLP1R), used for treating type 2 diabetes and obesity by enhancing insulin secretion, reducing glucagon levels, and promoting weight loss. It is available in subcutaneous and oral formulations.
Cancer Cell, 2025, 43(4):776-796.e14
Nat Commun, 2024, 15(1):7991
S9852 Orforglipron (LY3502970) Orforglipron (LY3502970) is a non-peptidal agonist of glucagon-like peptide 1 (GLP-1) receptor. It can be used efficiently in glycaemic control and weight reduction in type 2 diabetes mellitus (T2DM), obesity or both.
E7333 Semaglutide Sodium Semaglutide Sodium (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM).
Cancers (Basel), 2025, 17(4)598
P1247 Exendin-4 Exendin-4 (Exenatide) is a 39-amino acid peptide and a long-acting potent agonist of glucagon-like peptide-1(GLP-1) receptor with an IC50 of 3.22 nM. It is used in research and as a potential long-term treatment for type 2 diabetes mellitus.
Mater Today Bio, 2025, 33:102009
E1173 V-0219 V-0219 is an orally active, positive allosteric modulator (PAM) of the glucagon-like peptide-1 receptor (GLP-1R), can be used for obesity-associated diabetes research.
S3734 Albiglutide Fragment Albiglutide fragment is one copy of a 30-amino-acid sequence of modified human GLP-1 (fragment 7-36).
S0555 Adomeglivant Adomeglivant (LY2409021) is a potent and selective antagonist of glucagon receptor that is used as a chronic treatment for type 2 diabetes.
S8517 Lixisenatide Lixisenatide (Lyxumia, Adlyxin, ZP10A peptide, AVE0010) is a once-daily short-acting glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) with an IC50 of 1.4 nM for the human GLP-1 receptor in receptor binding studies.
S9935 Teduglutide (ALX-0600) Teduglutide (ALX-0600, Gattex, Revestive, TAK 633) is an analogue of human glucagon-like peptide-2 (GLP-2) and binds to the GLP-2 receptors. Teduglutide prolongs the intestinotrophic properties of GLP-2 in animal models.
E4779 DMB DMB (GLP-1R agonist 2, Compound 2) is an agonist of the GLP-1 receptor (GLP-1R) with a Ki of 13.25 µM. It activates GLP-1R by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues. This compound attenuates transient focal cerebral ischemia injury and inhibits neuronal apoptosis induced by MCAO.