GPR Inhibitors

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
E7448	[Pyr1]-Apelin-13	[Pyr1]-Apelin-13 is one of the endogenous agonists of the APJ receptor with high binding affinity Kd of 4.5 nM for hAPJ, predominantly found in the myocardium and plasma. It exhibits analgesic effects and improves cardiovascular function, making it a promising candidate for neuropathic pain and heart failure research.
S3451	PH-064	PH-064 (BIM-46187) is a novel imidazo-pyrazine derivative that effectively inhibits the heterotrimeric G-protein complex. This compound inhibits heterotrimeric G-protein signalling in GPCRs that mediate cyclic AMP generation (GAs), calcium release (GAq), cancer cell invasion by Wnt-2 frizzled receptors, and high-affinity neurotensin receptors (GAo/i and GAq).