Fatty Acid Synthase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S9785	Fatostatin	Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. This compound binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. It suppresses growth and enhances Apoptosis in cancer cells.	J Transl Med, 2025, 23(1):1055 iScience, 2025, 28(8):113097 Oncol Lett, 2025, 29(4):175
S9714	Denifanstat (TVB-2640)	Denifanstat (TVB-2640) is an orally bioavailable, pharmacological fatty acid synthase (FAS/FASN) inhibitor with therapeutic potential in patients with NAFLD and nonalcoholic steatohepatitis.	Nat Genet, 2024, 10.1038/s41588-024-01891-8 Cell Rep, 2023, 42(9):113034 J Transl Med, 2023, 21(1):32
S8563	TVB-3664	TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 M and 0.012 M for human and mouse cell palmitate synthesis, respectively.	bioRxiv, 2025, 2025.02.02.636110 Nat Commun, 2023, 14(1):1362 bioRxiv, 2023, 2023.07.05.547848
S1937	Isoniazid	Isoniazid is a prodrug that blocks the action of Fatty Acid Synthase by interacting with KatG, used for the prevention and treatment of tuberculosis.	mBio, 2022, e0302422. Nat Metab, 2021, 10.1038/s42255-021-00479-4 Front Immunol, 2021, 12:712021
S4754	Betulin	Betulin (BE, betulinol, betuline, betulinic alcohol), also known as betulinol, betuline, or betulinic alcohol, is a pentacyclic lupane-type triterpenoid naturally distributed in many plants and displays a broad spectrum of biological and pharmacological properties such as anticancer and chemopreventive activity. This compound (Trochol), is a sterol regulatory element-binding protein (SREBP) inhibitor with an IC50 of 14.5 μM in K562 cell line.	Acta Biochim Biophys Sin -Shanghai), 2023, 55(9):1479-1486 Acta Biochim Biophys Sin (Shanghai), 2023, 55(9):1479-1486 Nat Metab, 2021, 10.1038/s42255-021-00479-4
S6666	FT113	FT113 is a potent inhibitor of fatty acid synthase (FAS/FASN) with ic50 of 213 nM.	Oncotarget, 2025, 16:532-544 Nat Cancer, 2023, 4(10):1508-1525 Nat Cancer, 2023, 10.1038/s43018-023-00635-7
S8915	C75 trans	C75 trans (trans-C75, (±)-C75) is a novel, potent synthetic inhibitor of Fatty Acid Synthase (FAS/FASN) with IC50 of 35 μM and 50 μM in clonogenic assays and spheroid growth assay, respectively. C75 is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.	Biol Sex Differ, 2025, 16(1):9 Signal Transduct Target Ther, 2022, 7(1):46 Nat Metab, 2021, 10.1038/s42255-021-00479-4
S3300	Desoxyrhaponticin	Desoxyrhaponticin (DC, DES), a stilbene glycoside from Rheum tanguticum Maxim. ex Balf. (rhubarb) which is a traditional Chinese nutritional food, is a fatty acid synthase (FAS/FASN) inhibitor. This compound is also a competitive inhibitor of glucose uptake with IC50 of 148.3 μM and 30.9 μM in rabbit intestinal membrane vesicles and in rat everted gut sleeves, respectively. It has apoptotic effect on human cancer cells.	Nat Metab, 2021, 10.1038/s42255-021-00479-4
S9392	Praeruptorin B	Praeruptorin B is an important compound isolated from Bai-hua Qian-hu and has been reported to exert multiple biochemical and pharmacological activities. Praeruptorin B exerts lipid-lowering effects through inhibits SREBPs and could serve as a possible therapeutic option to improve hyperlipidaemia and hyperlipidaemia-induced comorbidities.	Nat Metab, 2021, 10.1038/s42255-021-00479-4
E2641	trans-Chalcone	Trans-Chalcone, the backbone of flavonoids, also is a potent Fatty Acid Synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cell cycle arrest and induces apoptosis in the breast cancer cell line MCF-7, exerting antifungal and anticancer activities.
E2667	IPI-9119	IPI-9119 is a potent, selective, and irreversible inhibitor of Fatty Acid Synthase (FASN), which can inhibit the FASN thioesterase domain by promoting acylation of the catalytic serine with an IC50 of 0.3 nM.
S3576	TVB-3166	TVB-3166 is an orally-available, reversible, potent and selective inhibitor of fatty acid synthase (FASN) with IC50 of 0.042 μM in an in vitro biochemical assay. This compound induces apoptosis, and inhibits in-vivo xenograft tumour growth.
S6248	Fasnall	Fasnall, a thiophenopyrimidine, is a selective fatty acid synthase (FASN) inhibitor that shows potent anti-tumour activity.
S2697	A-769662	A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM in cell-free assays, little effect on GPPase/FBPase activity.	FEBS J, 2025, 10.1111/febs.70247 Arch Biochem Biophys, 2025, 769:110433 J Clin Invest, 2024, 134(22)e181314
S2250	EGCG ((-)-Epigallocatechin Gallate)	EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.	Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694 Cell Rep, 2025, 44(6):115799 Front Pharmacol, 2024, 15:1403424
S2314	Kaempferol	Kaempferol, a natural flavonol, functions as an ERRα and ERRγ inverse agonist. It inhibits topoisomerase I catalysed DNA religation and may also inhibit the activity of Fatty Acid Synthase.	BMC Pharmacol Toxicol, 2025, 26(1):167 Int J Mol Sci, 2023, 24(19)14519 Front Pharmacol, 2023, 14:1047184
S1629	Orlistat	Orlistat is a general lipase inhibitor with IC50 of 122 ng/ml for PL from human duodenal juice. This compound treatment reduces proliferation, induces apoptosis and arrests cell cycle.	Cell Rep, 2025, 44(7):115901 Acta Pharmacol Sin, 2025, 10.1038/s41401-025-01477-y J Cell Sci, 2024, 137(20)jcs262162
S8284	Fatostatin HBr	Fatostatin HBr is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.	Cancer Commun (Lond), 2025, 10.1002/cac2.70038 Cell Commun Signal, 2025, 23(1):438 ACS Omega, 2024, 9(47):47042-47051