Taste Receptor
Other GPCR & G Protein Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S9006 | Perillartine | Perillartine (Perilla sugar, Peryllartine) is a sweetener. This compound can activate the Tas1r2 monomeric receptors of human, rhesus monkey and squirrel monkey but not mouse in a species-dependent manner. | ||
| S1273 | Amarogentin |
Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. This compound is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. It induces Apoptosis in human gastric cancer cells (SNU-16) through G2/M cell cycle arrest and PI3K/Akt signalling pathway. This chemical interacts with the α2 subunit of AMP-activated protein kinase (AMPK) and activates the trimeric kinase with EC50 of 277 pM. |
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| S2036 | Aspartame | Aspartame (SC-18862,Nutrasweet) is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. | ||
| S4022 | Probenecid | Probenecid (Benemid) is a classical competitive inhibitor of organic anion transport, which is also a TRPV2 agonist and an inhibitor of TAS2R16. This compound is also a clinically used broad-spectrum Pannexin1 (Panx1) blocker. |
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