Home Cytoskeletal Signaling -Cell Cycle PAK PAK1-Selective Inhibitors

PAK1-Selective Inhibitors

  • PAK1
  • PAK3
  • PAK2
  • PAK4
  • PAK5
  • PAK6
Cat.No. Product Name Information Selective / Pan IC50 / Ki
S7093 IPA-3 IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6). Selective PAK1, IC50: 2.5 μM
S7271 FRAX597 FRAX597 is a potent, ATP-competitive inhibitor of group I PAKs with IC50 of 8 nM, 13 nM, and 19 nM for PAK1, PAK2, and PAK3, respectively. Pan PAK1, IC50: 8 nM
S7094 PF-3758309 PF-03758309 is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 with IC50 of 1.3 nM. Pan PAK1, Ki: 13.7 nM