Home Neuronal Signaling -GPCR & G Protein 5-HT Receptor 5-HT6-Selective Antagonists

5-HT6-Selective Antagonists

  • 5-HT1
  • 5-HT2
  • 5-HT3
  • 5-HT4
  • 5-HT6
  • 5-HT7
  • 5-HT5
Cat.No. Product Name Information Selective / Pan IC50 / Ki
S2894 SB742457 SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2. Selective 5-HT6, pKi: 9.63
S2856 SB271046 SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes. Selective 5-HT6, pKi: 8.92
S1283 Asenapine Asenapine is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder. Pan 5-HT6, pKi: 9.6
S2677 BRL-15572 BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. Pan 5-HT6, pKi: 5.9
S1615 Risperidone Risperidone is a mutil-targeted antagonist for dopamine, serotonin, adrenergic and histamine receptors, used to treat schizophrenia and bipolar disorder. Pan 5-HT6, Ki: 2060 nM