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EIDD-1931 (NHC) SARS-CoV inhibitor

Name: EIDD-1931 (NHC)
Brand: Selleck Chemicals
SKU: S0833
Rating: 5 (6 reviews)

Cat.No.S0833

EIDD-1931 (NHC) is an active metabolite of EIDD-2801, a promising COVID-19 inhibitor. This compound has broad spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and related zoonotic group 2b or 2c Bat-CoVs with average IC50 of 0.15 μM, as well as increased potency against a coronavirus bearing resistance mutations to the nucleoside analog inhibitor remdesivir.

Chemical Structure

Molecular Weight: 259.22

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Quality Control

Batch: S083301 Water]15 mg/mL]false]Ethanol]3 mg/mL]false]]]false Purity: 99.73%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.73

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV
Other SARS-CoV Inhibitors	Molnupiravir (EIDD-2801) Nirmatrelvir (PF-07321332) Paquinimod (ABR-215757) Ensitrelvir fumarate Simnotrelvir ML188 XP-59 Bemnifosbuvir Hemisulfate (AT-527) Lufotrelvir (PF-07304814) TC-067533

Chemical Information, Storage & Stability

Molecular Weight	259.22	Formula	C₉H₁₃N₃O₆	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	3258-02-4	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Beta-d-N4-hydroxycytidine			Smiles	OCC1OC(C(O)C1O)N2C=C\C(NC2=O)=N\O

Solubility

In vitro
Batch:

Water : 15 mg/mL

Ethanol : 3 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Clear solution	5%ethyl alcohol 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.150mg/ml (0.58mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clarified ethyl alcohol stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% ethyl alcohol 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.150mg/ml (0.58mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear ethyl alcohol stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/32253226/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05386758	Completed	Renal Impairment	Merck Sharp & Dohme LLC	June 29 2022	Phase 1
NCT05386589	Completed	Hepatic Impairment	Merck Sharp & Dohme LLC	June 14 2022	Phase 1
NCT05061472	Active not recruiting	Contraceptive Usage\|Overweight or Obesity\|Body Weight Changes\|Appetitive Behavior\|Eating Behavior	University of Colorado Denver	May 23 2022	--

Tech Support

Handling Instructions

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