Name: Carbazochrome sodium sulfonate (AC-17)
Brand: Selleck Chemicals
SKU: S3000
Rating: 5 (9 reviews)

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Quality Control

Batch: S300001 DMSO]64 mg/mL]false]Water]3 mg/mL]false]Ethanol]Insoluble]false Purity: 99.57%

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COA
NMR
SDS
Datasheet

99.57

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Chemical Information, Storage & Stability

Molecular Weight	322.27	Formula	C₁₀H₁₁N₄NaO₅S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	51460-26-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CN1C(CC2=CC(=C(C=C21)O)N=NC(=O)N)S(=O)(=O)[O-].[Na+]

Solubility

In vitro
Batch:

DMSO : 64 mg/mL (198.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 3 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro	Carbazochrome (0.1–1 M) reverses the barrier dysfunction induced by tryptase, thrombin and bradykinin without affecting the endothelial permeability enhanced by Ca(2+) ionophores such as ionomycin and A23187 or phorbol 12-myristate 13-acetate. Carbazochrome reverses the tryptase-induced formation of actin stress fibres and disruption of VE-cadherin in the monolayers of cultured porcine aortic endothelial cells (PAECs). Carbazochrome (0.1-10 M) reduces concentration-dependently the enhancement of [(3)H]inositol triphosphate formation from [(3)H]myo-inositol induced by bradykinin and thrombin. Carbazochrome significantly blocks the hyperpermeability induced in cultured bovine endothelial cells by tryptase, thrombin and proteinase-activated receptor-2 agonist peptide (SLIGKV-NH(2)). Carbazochrome significantly decreases the t-PA:Ag in the culture medium of human umbilical vein endothelial cells (HUVEC), while it has no significant effect on the PAI-1:Ag.
In vivo	Carbazochrome (10 mg/kg) reverses the ioxaglate-induced vascular hyperpermeability in a dose-dependent manner in rats. Carbazochrome (10 mg/kg) significantly inhibits the decrease in arterial pO(2).
References	[1] https://pubmed.ncbi.nlm.nih.gov/12928765/ [2] https://pubmed.ncbi.nlm.nih.gov/12206859/ [3] https://pubmed.ncbi.nlm.nih.gov/7654937/

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Carbazochrome sodium sulfonate (AC-17)

Chemical Structure

Molecular Weight: 322.27