For research use only. Not for use in humans.

Anti-PDGFRB / CD140b (IMC-2C5)

Synonyms: IMC-2C5 Cat.No.A3043 Purity:99%

Anti-PDGFRB / CD140b (IMC-2C5) is a fully human antagonistic antibody targeting PDGFRβ It enhances antitumor activity and antiangiogenic agents in the treatment of a broad range of human cancers. MW :145.06 KD.

Quality Control

Batch: A304301 Purity: 99% Protein concentration: 8.7mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

Name	Citation	PDGFR	PDGFRα	PDGFRβ	Others
Dovitinib (TKI-258)	52			+++	FLT3,c-Kit,VEGFR3/FLT4
Linifanib (ABT-869)	33			++	VEGFR1/FLT1,CSF-1R,VEGFR2/KDR
Crenolanib (CP-868596)	99		++++	++++
Masitinib	42		+	+	Kit,Lyn B,Abl1
Amuvatinib (MP-470)	21		++		c-Kit (D816H),FLT3 (D835Y)
Motesanib Diphosphate (AMG-706)	12	++			VEGFR1,VEGFR2,VEGFR2/Flk1
Orantinib (SU6668)	21			+++
CP-673451	36		+++	++++
Ki8751	21		++		VEGFR2,c-Kit
Telatinib	5		+++		c-Kit,VEGFR3,VEGFR2
PP121	5	++++			Hck,VEGFR,mTOR
MK-2461	4			+++	c-Met (M1250T),c-Met (Y1235D),c-Met (Y1230H)
Tyrphostin AG 1296	14	+			c-Kit (Swiss 3T3),FGFR (Swiss 3T3)
Tyrphostin 9	1	+			EGFR
Dovitinib (TKI258) Lactate monohydrate	31			+++	FLT3,c-Kit,FGFR1
AZD2932	3			+++	Flt3,VEGFR-2,c-Kit
Sennoside B	0	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-PDGFRB / CD140b (IMC-2C5) is a fully human antagonistic antibody targeting PDGFRβ It enhances antitumor activity and antiangiogenic agents in the treatment of a broad range of human cancers. MW :145.06 KD.
References	[1] https://pubmed.ncbi.nlm.nih.gov/19484148/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Isotype	Human IgG1
Source	CHO
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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