research use only

Difelikefalin

Cat.No.P1151

Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.

Amino-acid Sequence

CAS No. 1024828-77-0

Quality Control

Batch: P115101 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 99.69%

99.69

Chemical Information & Solubility

Storage (from the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL (147.09 mM)；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molecular Weight Calculator

In Vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	Difelikefalin (CR-845, FE-202845), a peripherally restricted and selective agonist of kappa opioid receptor (KOR), produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease.
Targets/IC₅₀/Ki	kappa opioid receptor

References
https://pubmed.ncbi.nlm.nih.gov/32405581/ https://pubmed.ncbi.nlm.nih.gov/31702883/

References

https://pubmed.ncbi.nlm.nih.gov/32405581/
https://pubmed.ncbi.nlm.nih.gov/31702883/

Product Information

Molecular Formula	C₃₆H₅₃N₇O₆
Molecular Weight	679.85
CAS No.	1024828-77-0
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)