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Bremelanotide Acetate

Cat.No.P1108

Bremelanotide Acetate (PT-141 Acetate) is a Melanocortin Receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalised hypoactive sexual desire disorder (HSDD), as characterised by low sexual desire that causes marked distress or interpersonal difficulty.

Amino-acid Sequence

CAS No. 1607799-13-2

Quality Control

Batch: P110801 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 99.97%

99.97

Chemical Information & Solubility

Storage (from the date of receipt)	3 years-20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL (92.14 mM)；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

Molecular Weight Calculator

In Vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Biological Activity

Description	Bremelanotide Acetate (PT-141 Acetate) is a Melanocortin Receptor (MCR) agonist recently approved in the USA for the treatment of premenopausal women with acquired, generalised hypoactive sexual desire disorder (HSDD), as characterised by low sexual desire that causes marked distress or interpersonal difficulty.

In Vivo
In Vivo	Bremelanotide, an analogue of the naturally occurring peptide a-MSH, activates the medial preoptic area (mPOA) and other hypothalamic and limbic regions of the brain involved in sexual behaviour, and may work by activating dopamine terminals in the mPOA.
Animal Research	Animal Models	rat model of sexual desire
	Dosages	5, 100, 200, 800 μg/kg
	Administration	s.c.

References
https://pubmed.ncbi.nlm.nih.gov/31429064/ https://pubmed.ncbi.nlm.nih.gov/17958619/

References

https://pubmed.ncbi.nlm.nih.gov/31429064/
https://pubmed.ncbi.nlm.nih.gov/17958619/

Product Information

Molecular Formula	C₅₀H₆₈N₁₄O₁₀.C₂H₄O₂
Molecular Weight	1085.22
CAS No.	1607799-13-2
Appearance	White Powder
Peptide Content (by %N)	≥80%
Single Impurity (by HPLC)	≤1.0%
Assay (By Anhydrous, Acetic Acid-free)	95.0~105.0%
MS	Consistent
Packing	plastic vial(dedicated for peptide packing) or glass vial, quantity according to customer's detail requirement.
Storage (From the date of receipt)	3 years-20°C powder
Shipping	Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)