PAK Inhibitors

Featured Inhibitors
Inhibitors (12)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S8032	PRT062607 (P505-15) HCl	PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.	Sci Adv, 2025, 11(31):eadu4270 Sci Rep, 2024, 14(1):7739 J Exp Med, 2023, 220(9)e20230054
S8444	Padnarsertib (KPT-9274, ATG-019)	Padnarsertib (KPT 9274) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.	Signal Transduct Target Ther, 2025, 10(1):222 Cell Rep Med, 2024, 5(2):101416 Sci Rep, 2023, 13(1):3334

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S8032

PRT062607 (P505-15) HCl

PRT062607 (P505-15, BIIB057, PRT-2607) HCl is a novel, highly selective Syk inhibitor with IC50 of 1 nM in cell-free assays, >80-fold selective for Syk than Fgr, PAK5, Lyn, FAK, Pyk2, FLT3, MLK1 and Zap70.

Sci Adv, 2025, 11(31):eadu4270

Sci Rep, 2024, 14(1):7739

J Exp Med, 2023, 220(9)e20230054

Verified customer review of PRT062607 (P505-15) HCl

S8444

Padnarsertib (KPT-9274, ATG-019)

Padnarsertib (KPT 9274) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.

Signal Transduct Target Ther, 2025, 10(1):222

Cell Rep Med, 2024, 5(2):101416

Sci Rep, 2023, 13(1):3334