| S2597 |
Oseltamivir Phosphate
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Oseltamivir Phosphate (Tamiflu) is a potent and selective inhibitor of the Neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.
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Nat Commun, 2025, 16(1):6271
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Int J Biol Macromol, 2025, 330(Pt 3):148150
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Clin Immunol, 2024, 262:110178
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| S2716 |
Peramivir Trihydrate
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Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific Influenza Virus Neuraminidase inhibitor with an IC50 of median 0.09 nM.
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Viruses, 2024, 16(9)1467
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Emerg Microbes Infect, 2014, 3(11):e78
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Emerg Microbes Infec, 2014, 3, e78
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| S3007 |
Zanamivir
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Zanamivir (GG167,GR 121167X) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.
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Front Immunol, 2019, 10:2575
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Emerg Microbes Infect, 2014, 3(11):e78
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Emerg Microbes Infec, 2014, 3, e78
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| E4968 |
Oseltamivir
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Oseltamivir (GS 4104) is an orally administered antiviral that selectively inhibits influenza neuraminidase enzymes, essential for viral replication. It is used for the treatment and prevention of influenza A and B infections.
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Drug Metab Dispos, 2025, 53(4):100049
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| E4607 |
Oseltamivir acid
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Oseltamivir acid (GS 4071, Ro 64-0802, Oseltamivir carboxylate), a metabolite of the antiviral compound oseltamivir, acts as a competitive inhibitor of influenza neuraminidases A and influenza neuraminidases B with IC50 of 0.1 to 4.9 nM respectively, thereby preventing virus budding and release.
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| S0861 |
Laninamivir Octanoate
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Laninamivir Octanoate (CS-8958, R-118958, Inavir, LANI), a prodrug of Laninamivir (R-125489), is a long-acting neuraminidase (NA) inhibitor with superior anti-Influenza Virus activity.
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| E4879 |
Laninamivir
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Laninamivir (R-125489) is a potent inhibitor of influenza neuraminidase (NA) with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively. It exhibits long-acting anti-influenza virus activity.
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| E7266 |
Aurintricarboxylic acid
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Aurintricarboxylic acid is a potent, selective allosteric antagonist of P2X1R and P2X3R, with IC50 of 8.6 nM and 72.9 nM, respectively. It also functions as an anti-influenza agent by inhibiting viral neuraminidase. This compound suppresses apoptosis and is a potent inhibitor of topoisomerase II with an ID50 of ~7 nM in relaxation assays.
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| E0109 |
Fezolinetant
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Fezolinetant (ESN-364) is a potential antagonist of the neurokinin 3 receptor (NK3R). It interrupts pulsatile lh secretion and moderates levels of ovarian hormones throughout the menstrual cycle.
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